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. 1988 Mar 25;16(5):2323-32.
doi: 10.1093/nar/16.5.2323.

Hydrogen-bonding effects and 13C-NMR of the DNA double helix

P N Borer  1 , S R LaPlante, N Zanatta, G C Levy
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Free PMC article

Hydrogen-bonding effects and 13C-NMR of the DNA double helix

P N Borer et al. Nucleic Acids Res. .
Free PMC article

Abstract

13C-nmr chemical shifts of the nucleotides in DNA are sensitive to hydrogen bonding, especially for three of the carbons immediately bonded to exocyclic oxygen or nitrogen atoms acting as H-bond acceptors or donors. GuoC2, GuoC6 and ThdC4 are strongly deshielded (about 1 ppm) upon Watson-Crick pairing in oligodeoxynucleotide duplexes, regardless of the base sequence. Deshielding at these sites may be useful to distinguish bases involved in Watson-Crick pairs from unpaired bases.

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