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Review
. 2021 Jun;36(3):483-491.
doi: 10.1002/jca.21883. Epub 2021 Feb 12.

The use of therapeutic plasma exchange as adjunctive therapy in the treatment of coronavirus disease 2019: A critical appraisal of the current evidence

Wen Lu  1 , Walter Kelley  2   3 , Deanna C Fang  4 , Sarita Joshi  5 , Young Kim  6 , Monika Paroder  7 , Yvette Tanhehco  8 , Minh-Ha Tran  9 , Huy P Pham  10
Affiliations
Review

The use of therapeutic plasma exchange as adjunctive therapy in the treatment of coronavirus disease 2019: A critical appraisal of the current evidence

Wen Lu et al. J Clin Apher. 2021 Jun.

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a major pandemic. While vaccine development moves forward, optimal treatment continues to be explored. Efforts include an ever-expanding number of clinical trials along with newly proposed experimental and off-label investigational therapies; one of which is therapeutic plasma exchange (TPE). There have been a number of publications on TPE use as adjunctive therapy for coronavirus disease 2019 (COVID-19), but no prospective randomized controlled trials (RCTs) have been completed. This article critically appraises the current available evidence on TPE as a treatment modality for SARS-CoV-2 infection.

Keywords: COVID-19; SARS-CoV-2; plasma exchange.

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Conflict of interest statement

The authors declare no conflict of interest.

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