Ocular manifestations of dengue fever in University Malaya Medical Centre

Abstract

This time-framed study describes the spectrum of ocular manifestations in patients with dengue fever and the association between maculopathy with the stages of dengue fever. This cross sectional prospective study involved 145 dengue inpatients recruited from University Malaya Medical Centre. Observed parameters were stages of dengue infection, abnormal fundus and types of maculopathy. Retinal abnormalities involved the peripheral region in 3 patients (1.03%) and the macula in 13 patients (4.48%). The types of maculopathy encountered were macular oedema 7 (53.8%), cystic appearance 4 (30.8%), macular haemorrhage 1 (7.7%) and yellow spots 1(7.7%). Reduced distance VA, visual scotoma and metamorphopsia and abnormal Amsler grid test correlated with maculopathy, p< 0.05. Maculopathy correlated well with dengue with severe leakage (p= 0.025). Our study found the prevalence of maculopathy in dengue infection to be 4.48% in UMMC. The significant predictors of maculopathy were dengue with severe leakage, visual scotoma, metamorphopsia, distance VA impairment and abnormal Amsler grid test. This study was funded by a University Malaya Grant - URMG no: RP006D-13HTM.