Reply to 'Hypothermic machine perfusion before viability testing of previously discarded human livers'

Hynek Mergental^{1

2

3}, Richard W Laing^{4

5

6}, Simon C Afford^{5

6}, Darius F Mirza^{4

5

6}

Affiliations

¹ Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. hynek.mergental@uhb.nhs.uk.
² National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. hynek.mergental@uhb.nhs.uk.
³ Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. hynek.mergental@uhb.nhs.uk.
⁴ Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
⁵ National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
⁶ Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

PMID: 33579911
PMCID: PMC7881196
DOI: 10.1038/s41467-021-21183-7

Comment

Reply to 'Hypothermic machine perfusion before viability testing of previously discarded human livers'

Hynek Mergental et al. Nat Commun. 2021.

. 2021 Feb 12;12(1):1015.

doi: 10.1038/s41467-021-21183-7.

Authors

Hynek Mergental^{1

2

3}, Richard W Laing^{4

5

6}, Simon C Afford^{5

6}, Darius F Mirza^{4

5

6}

Affiliations

¹ Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. hynek.mergental@uhb.nhs.uk.
² National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. hynek.mergental@uhb.nhs.uk.
³ Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. hynek.mergental@uhb.nhs.uk.
⁴ Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
⁵ National Institute for Health Research (NIHR), Birmingham Biomedical Research Centre, University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
⁶ Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

PMID: 33579911
PMCID: PMC7881196
DOI: 10.1038/s41467-021-21183-7

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Comment on

Transplantation of discarded livers following viability testing with normothermic machine perfusion.
Mergental H, Laing RW, Kirkham AJ, Perera MTPR, Boteon YL, Attard J, Barton D, Curbishley S, Wilkhu M, Neil DAH, Hübscher SG, Muiesan P, Isaac JR, Roberts KJ, Abradelo M, Schlegel A, Ferguson J, Cilliers H, Bion J, Adams DH, Morris C, Friend PJ, Yap C, Afford SC, Mirza DF. Mergental H, et al. Nat Commun. 2020 Jun 16;11(1):2939. doi: 10.1038/s41467-020-16251-3. Nat Commun. 2020. PMID: 32546694 Free PMC article. Clinical Trial.
Hypothermic machine perfusion before viability testing of previously discarded human livers.
van Leeuwen OB, de Vries Y, de Meijer VE, Porte RJ. van Leeuwen OB, et al. Nat Commun. 2021 Feb 12;12(1):1008. doi: 10.1038/s41467-021-21182-8. Nat Commun. 2021. PMID: 33579908 Free PMC article. No abstract available.

References

1. van Leeuwen, O. B. et al. Hypothermic machine perfusion before viability testing of previously discarded human livers Nat. Commun.10.1038/s41467-021-21182-8 (2021). - PMC - PubMed
1. Mergental H, et al. Transplantation of discarded livers following viability testing with normothermic machine perfusion. Nat. Commun. 2020;11:2939. doi: 10.1038/s41467-020-16251-3. - DOI - PMC - PubMed
1. Nasralla D, et al. A randomized trial of normothermic preservation in liver transplantation. Nature. 2018;557:50–56. doi: 10.1038/s41586-018-0047-9. - DOI - PubMed
1. Martins, P. N., Buchwald, J. E., Mergental, H., Vargas, L. & Quintini, C. The role of normothermic machine perfusion in liver transplantation. Int. J. Surg. 10.1016/j.ijsu.2020.05.026 (2020). - PubMed
1. Laing, R. W. et al. The Delivery of Multipotent Adult Progenitor Cells to Extended Criteria Human Donor Livers Using Normothermic Machine Perfusion. Front. Immunol.11, 10.3389/fimmu.2020.01226 (2020). - PMC - PubMed

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Reply to 'Hypothermic machine perfusion before viability testing of previously discarded human livers'

Affiliations

Reply to 'Hypothermic machine perfusion before viability testing of previously discarded human livers'

Authors

Affiliations

Conflict of interest statement

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References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical