Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021:49:17-30.
doi: 10.1007/7854_2020_195.

On the Development of OCD

Affiliations
Review

On the Development of OCD

T U Hauser. Curr Top Behav Neurosci. 2021.

Abstract

OCD most often arises before adulthood with adolescence being a particularly vulnerable period. This is also a time when both brain and cognition undergo fundamental developmental change and reorganisation. However, the neurocognitive mechanisms that drive the emergence of OCD during development are still largely unknown. In this chapter, I review the relatively sparse literature on the developmental aspects of OCD and I discuss the symptomatic, cognitive and neural patterns in OCD and the developing mind. I highlight how we need to understand the emergence of cognitive impairments and neural alteration in a developmental context if we want to understand more about the mechanisms that give rise to OCD. Moreover, I outline how we best approach this challenge to overcome the current limitations in research.

Keywords: Developmental computational psychiatry; Juvenile OCD; Longitudinal studies.

PubMed Disclaimer

References

    1. Benatti B, Camuri G, Dell’Osso B, Cremaschi L, Sembira E, Palazzo C, Oldani L, Dobrea C, Arici C, Primavera D, Carpiniello B, Castellano F, Carrà G, Clerici M, Baldwin DS, Altamura AC (2016) Which factors influence onset and latency to treatment in generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder? Int Clin Psychopharmacol 31:347–352 - PubMed - DOI
    1. Boedhoe PSW et al (2016) Distinct subcortical volume alterations in pediatric and adult OCD: a worldwide meta- and mega-analysis. Am J Psychiatry 174:60–69. https://doi.org/10.1176/appi.ajp.2016.16020201 - DOI - PubMed - PMC
    1. Boedhoe PSW et al (2018) Cortical abnormalities associated with pediatric and adult obsessive-compulsive disorder: findings from the ENIGMA obsessive-compulsive disorder working group. Am J Psychiatry 175:453–462 - PubMed - DOI
    1. Brem S, Hauser TU, Iannaccone R, Brandeis D, Drechsler R, Walitza S (2012) Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder: a review of literature and preliminary meta-analysis. J Neural Transm Vienna Austria 119:1425–1448 - DOI
    1. Carlisi CO, Norman L, Murphy CM, Christakou A, Chantiluke K, Giampietro V, Simmons A, Brammer M, Murphy DG, Mataix-Cols D, Rubia K (2017) Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder. Psychol Med 47:2513–2527 - PubMed - PMC - DOI

LinkOut - more resources