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Review
. 2021 Aug;236(8):5512-5532.
doi: 10.1002/jcp.30276. Epub 2021 Feb 12.

Signaling, metabolism, and cancer: An important relationship for therapeutic intervention

Mostafa Vaghari-Tabari  1   2 , Gordon A Ferns  3 , Durdi Qujeq  4   5 , Ali Nosrati Andevari  6 , Zahra Sabahi  7 , Soheila Moein  7
Affiliations
Review

Signaling, metabolism, and cancer: An important relationship for therapeutic intervention

Mostafa Vaghari-Tabari et al. J Cell Physiol. 2021 Aug.

Abstract

In cancerous cells, significant changes occur in the activity of signaling pathways affecting a wide range of cellular activities ranging from growth and proliferation to apoptosis, invasiveness, and metastasis. Extensive changes also happen with respect to the metabolism of a cancerous cell encompassing a wide range of functions that include: nutrient acquisition, biosynthesis of macromolecules, and energy generation. These changes are important and some therapeutic approaches for treating cancers have focused on targeting the metabolism of cancerous cells. Oncogenes and tumor suppressor genes have a significant effect on the metabolism of cells. There appears to be a close interaction between metabolism and the signaling pathways in a cancerous cell, in which the interaction provides the metabolic needs of a cancerous cell for uncontrolled proliferation, resistance to apoptosis, and metastasis. In this review, we have reviewed the latest findings in this regard and briefly review the most recent research findings regarding targeting the metabolism of cancer cells as a therapeutic approach for treatment of cancer.

Keywords: cancer; cancer treatment; metabolism; signaling pathways.

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References

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