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Review
. 2021 Apr:232:35-38.
doi: 10.1016/j.imlet.2021.02.002. Epub 2021 Feb 10.

Influence of aging on T cell response and renin-angiotensin system imbalance during SARS-CoV-2 infection

Jorge Quarleri  1 , Cintia Cevallos  2 , M Victoria Delpino  3
Affiliations
Review

Influence of aging on T cell response and renin-angiotensin system imbalance during SARS-CoV-2 infection

Jorge Quarleri et al. Immunol Lett. 2021 Apr.
No abstract available

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Figures

Fig. 1
Fig. 1
RAS and T cell response following SARS-CoV-2 infection during controlled (A) and uncontrolled (B) disease. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) into Ang 1-7, inactivating Ang II. Ang 1-7 via MAS receptor antagonizes inflammatory response allowing an effective Th1 response (A). During acute pulmonary infection diseases, RAS participates in the development of ARDS with consequent pulmonary fibrosis. The unbalance between AngII and Ang 1-7 inducing the differentiation of Th17 cells that secrete numerous cytokines. In particular, IL-17 per se induces the production of massive quantities of proinflammatory cytokines and chemokines (B).
See this image and copyright information in PMC

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