Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug 30;51(4):1601-1614.
doi: 10.3906/sag-2011-235.

Autoimmunity in psoriatic arthritis: pathophysiological and clinical aspects

Hakan Emmungil  1 , Ufuk İlgen  1 , Rafi Haner Direskeneli  2
Affiliations
Review

Autoimmunity in psoriatic arthritis: pathophysiological and clinical aspects

Hakan Emmungil et al. Turk J Med Sci. .

Abstract

Psoriatic arthritis (PsA) is an underdiagnosed entity with a broad impact on the quality of life. Although the pathogenesis is largely unknown, autoimmune footprints of the inflammation in PsA have increasingly been recognized. Most of the genetic variation predisposing to PsA is mapped to the class I major histocompatibility complex (MHC) region and shared by a variety of autoimmune diseases. Polymorphisms in the genes IL12B, IL23R, IL13, TNIP1, TRAF3IP2, TYK2, and many others explain the non- HLA genetic risk with little known functional consequences. Entheseal and synovial cellular infiltrate with oligoclonal CD8+ T cells and occasional germinal centers, loss of regulatory T cell function, and specific autoantibodies such as anti-PsA peptide, anti-LL-37, and anti-ADAMTSL5 are the immunopathological findings suggestive of autoimmunity. These were supported by clinical observations of autoimmune multimorbidity and treatment response to calcineurin/mTOR and co-stimulation inhibition.

Keywords: Autoantibody; autoimmunity; genetic; psoriasis; psoriatic arthritis.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST:

none declared

Figures

Figure 1
Figure 1
Genes implicated in susceptibility to psoriasis and psoriatic arthritis.
See this image and copyright information in PMC

References

    1. Prey S Paul C Bronsard V Puzenat E Gourraud PA Assessment of risk of psoriatic arthritis in patients with plaque psoriasis: a systematic review of the literature. Journal of the European Academy of Dermatology and Venereology. 2010;24:31–35. - PubMed
    1. Alenius GM Stenberg B Stenlund H Lundblad M Dahlqvist SR Inflammatory joint manifestations are prevalent in psoriasis: prevalence study of joint and axial involvement in psoriatic patients, and evaluation of a psoriatic and arthritic questionnaire. The Journal of Rheumatology. 2002;29:2577–2582. - PubMed
    1. Reich K Krüger K Mössner R Augustin M. Epidemiology and clinical pattern of psoriatic arthritis in Germany: a prospective interdisciplinary epidemiological study of 1511 patients with plaque-type psoriasis. British Journal of Dermatology. 2009;160:1040–1047. - PubMed
    1. Mease PJ Menter MA Quality-of-life issues in psoriasis and psoriatic arthritis: outcome measures and therapies from a dermatological perspective. Journal of the American Academy of Dermatology. 2006;54:685–704. - PubMed
    1. Gudu T Gossec L Quality of life in psoriatic arthritis. Expert Review of Clinical Immunology. 2018;14:405–417. - PubMed

MeSH terms