[The dose-effect relationship in connection with the study of the interaction of chemical carcinogens]

Abstract

Problems arising in studies of the co-action of carcinogenic chemicals may be approached using mathematical models of dose-response dependence. It is shown that approximation of the dose-response dependence of chemical carcinogenesis co-factors can be obtained with the aid of a second-order polynomial. The planning of relevant experiments and studies of dose-response dependence models should be based on application of mathematical planning procedures, namely, second-order plans. Certain plans are recommended.