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. 2021 May;17(5):866-887.
doi: 10.1002/alz.12253. Epub 2021 Feb 13.

The search for a convenient procedure to detect one of the earliest signs of Alzheimer's disease: A systematic review of the prediction of brain amyloid status

Miriam T Ashford  1   2 , Dallas P Veitch  1 , John Neuhaus  3 , Rachel L Nosheny  2   4 , Duygu Tosun  5 , Michael W Weiner  1   2   4   5   6   7
Affiliations

The search for a convenient procedure to detect one of the earliest signs of Alzheimer's disease: A systematic review of the prediction of brain amyloid status

Miriam T Ashford et al. Alzheimers Dement. 2021 May.

Abstract

Introduction: Convenient, cost-effective tests for amyloid beta (Aβ) are needed to identify those at higher risk for developing Alzheimer's disease (AD). This systematic review evaluates recent models that predict dichotomous Aβ. (PROSPERO: CRD42020144734).

Methods: We searched Embase and identified 73 studies from 29,581 for review. We assessed study quality using established tools, extracted information, and reported results narratively.

Results: We identified few high-quality studies due to concerns about Aβ determination and analytical issues. The most promising convenient, inexpensive classifiers consist of age, apolipoprotein E genotype, cognitive measures, and/or plasma Aβ. Plasma Aβ may be sufficient if pre-analytical variables are standardized and scalable assays developed. Some models lowered costs associated with clinical trial recruitment or clinical screening.

Discussion: Conclusions about models are difficult due to study heterogeneity and quality. Promising prediction models used demographic, cognitive/neuropsychological, imaging, and plasma Aβ measures. Further studies using standardized Aβ determination, and improved model validation are required.

Keywords: PROBAST; QUADAS-2; amyloid beta; prediction models; systematic review.

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References

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