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Review
. 2021 Feb 15;32(6):597-613.
doi: 10.1515/revneuro-2020-0132. Print 2021 Aug 26.

Default mode network activity in depression subtypes

Bernard J Borserio  1 , Christopher F Sharpley  1   2 , Vicki Bitsika  1 , Kimaya Sarmukadam  1 , Phillip J Fourie  1 , Linda L Agnew  1
Affiliations
Review

Default mode network activity in depression subtypes

Bernard J Borserio et al. Rev Neurosci. .

Abstract

Depression continues to carry a major disease burden worldwide, with limitations on the success of traditional pharmacological or psychological treatments. Recent approaches have therefore focused upon the neurobiological underpinnings of depression, and on the "individualization" of depression symptom profiles. One such model of depression has divided the standard diagnostic criteria into four "depression subtypes", with neurological and behavioral pathways. At the same time, attention has been focused upon the region of the brain known as the "default mode network" (DMN) and its role in attention and problem-solving. However, to date, no review has been published of the links between the DMN and the four subtypes of depression. By searching the literature studies from the last 20 years, 62 relevant papers were identified, and their findings are described for the association they demonstrate between aspects of the DMN and the four depression subtypes. It is apparent from this review that there are potential positive clinical and therapeutic outcomes from focusing upon DMN activation and connectivity, via psychological therapies, transcranial magnetic stimulation, and some emerging pharmacological models.

Keywords: DMN; depression; diagnosis.

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References

    1. Albert, K.M., Potter, G.G., Boyd, B.D., Kang, H., and Taylor, W.D. (2019). Brain network functional connectivity and cognitive performance in major depressive disorder. J. Psychiatr. Res. 110: 51–56, https://doi.org/10.1016/j.jpsychires.2018.11.020.
    1. Al-Harbi, K.S. (2012). Treatment-resistant depression: therapeutic trends, challenges, and future directions. Patient Prefer. Adherence 6: 369–388, https://doi.org/10.2147/ppa.s29716.
    1. Andrews-Hanna, J.R. (2012). The brain’s default network and its adaptive role in internal mentation. Neuroscientist 18: 251–270, https://doi.org/10.1177/1073858411403316.
    1. Andrews-Hanna, J., Reidler, J., Sepulcre, J., Poulin, R., and Buckner, R. (2010). Functional-anatomic fractionation of the brain’s default network. Neuron 65: 550–562, https://doi.org/10.1016/j.neuron.2010.02.005.
    1. APA (2013). Diagnostic and statistical manual of mental disorders, 5th ed. Arlington, VA: American Psychiatric Association.

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