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Comment
. 2021 Aug:204:138-140.
doi: 10.1016/j.thromres.2021.02.008. Epub 2021 Feb 9.

ADAMTS 13 deficiency is associated with abnormal distribution of von Willebrand factor multimers in patients with COVID-19

Tiffany Pascreau  1 , Sara Zia-Chahabi  2 , Benjamin Zuber  3 , Colas Tcherakian  4 , Eric Farfour  2 , Marc Vasse  5
Affiliations
Comment

ADAMTS 13 deficiency is associated with abnormal distribution of von Willebrand factor multimers in patients with COVID-19

Tiffany Pascreau et al. Thromb Res. 2021 Aug.
No abstract available

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
(A) ADAMTS 13 antigen concentration in patients with COVID-19 compared to 21 healthy controls. ADAMTS 13 concentration were compared between the four groups (control, home, non-ICU and ICU) using the Kruskal-Wallis test followed by Dunn's posttest. ** p < 0.01 versus control group; ****p < 0.0001 versus control group, (B) Correlation between ADAMTS 13 antigen level and Willebrand antigen or C-reactive protein. Correlations were assessed using the Spearman coefficient correlation test. (C) ROC curve analysis of ADAMTS 13 level to predict ICU admission. (D) Distribution of von Willebrand factor multimers in a representative plasma from patient with COVID-19 (dark area) using agarose gel electrophoresis, compared to control (white area). VWF antigen of 517%, ADAMTS 13 antigen of 263 ng/mL, densitometry LMWM 28.1% (reference intervals 9–21%), IMWM 37.9% (reference intervals 22–36%) and HMWM 34% (reference intervals 45–67%). Ns: not significant; R: Spearman correlation coefficient; ICU: intensive care unit; AUC: Area under curve; LMWF: Low molecular weight multimers; IMWM: Intermediate molecular weight multimers; HMWM: High molecular weight multimers.
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