Cutaneous Cancer Biology

Alok R Khandelwal¹, Kristen A Echanique², Maie St John³, Cherie Ann Nathan⁴

Affiliations

¹ Department of Otolaryngology, Head and Neck Surgery, LSU Health Sciences Center, Shreveport, LA 71130, USA.
² Department of Head and Neck Surgery, University of California, Los Angeles Medical Center, 10833 Le Conte Avenue, CHS 62-132, Los Angeles, CA 90095, USA.
³ Department of Head and Neck Surgery, University of California, Los Angeles Medical Center, 10833 Le Conte Avenue, CHS 62-132, Los Angeles, CA 90095, USA; Department of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, USA; UCLA Head and Neck Cancer Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
⁴ Department of Otolaryngology/HNS, LSU Health-SHV, Feist-Weiller Cancer Center, 1501 Kings Highway, Shreveport, LA 71130, USA. Electronic address: cnatha@lsuhsc.edu.

PMID: 33583599
DOI: 10.1016/j.otc.2020.11.002

Review

Cutaneous Cancer Biology

Alok R Khandelwal et al. Otolaryngol Clin North Am. 2021 Apr.

. 2021 Apr;54(2):259-269.

doi: 10.1016/j.otc.2020.11.002. Epub 2021 Feb 11.

Authors

Alok R Khandelwal¹, Kristen A Echanique², Maie St John³, Cherie Ann Nathan⁴

Affiliations

¹ Department of Otolaryngology, Head and Neck Surgery, LSU Health Sciences Center, Shreveport, LA 71130, USA.
² Department of Head and Neck Surgery, University of California, Los Angeles Medical Center, 10833 Le Conte Avenue, CHS 62-132, Los Angeles, CA 90095, USA.
³ Department of Head and Neck Surgery, University of California, Los Angeles Medical Center, 10833 Le Conte Avenue, CHS 62-132, Los Angeles, CA 90095, USA; Department of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, USA; UCLA Head and Neck Cancer Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
⁴ Department of Otolaryngology/HNS, LSU Health-SHV, Feist-Weiller Cancer Center, 1501 Kings Highway, Shreveport, LA 71130, USA. Electronic address: cnatha@lsuhsc.edu.

PMID: 33583599
DOI: 10.1016/j.otc.2020.11.002

Abstract

There has been a drastic increase in the incidence of nonmelanoma (NMSC), including squamous, basal cell, and melanoma skin cancers worldwide. Most cases of skin cancer can be treated effectively with surgery; fewer than 10% of cases are advanced and may require additional therapies. A better understanding of the biology of skin cancer will help contribute to better prognostic information and identification of possible new therapeutic targets. Herein, the authors review the biology and pathogenesis of both NMSC and melanoma, focusing on critical cell signaling pathways mediating the disease and current therapeutic strategies targeted to underlying genetic pathways.

Keywords: Basal cell carcinoma; Cutaneous skin cancer; Head and neck cancer; Melanoma; Merkel cell carcinoma; Squamous cell carcinoma.

Published by Elsevier Inc.

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Conflict of interest statement

Disclosure The authors have no commercial or financial conflicts of interest pertaining to this article.

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Cutaneous Cancer Biology

Affiliations

Cutaneous Cancer Biology

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical