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. 2020 Oct;13(10):E53-E58.
Epub 2020 Oct 1.

A Split-face, Controlled Study to Assess the Compatibility of Tretinoin 0.05% Acne Lotion with Facial Foundation Makeup

Neal Bhatia  1   2   3   4 , Leon H Kircik  1   2   3   4 , Ava Shamban  1   2   3   4 , Varsha Bhatt  1   2   3   4 , Radhakrishnan Pillai  1   2   3   4 , Eric Guenin  1   2   3   4
Affiliations

A Split-face, Controlled Study to Assess the Compatibility of Tretinoin 0.05% Acne Lotion with Facial Foundation Makeup

Neal Bhatia et al. J Clin Aesthet Dermatol. 2020 Oct.

Abstract

OBJECTIVE: This study was conducted to assess compatibility of tretinoin 0.05% acne lotion with foundation makeup. DESIGN: This was a single-center, evaluator-blinded, randomized, controlled clinical trial. Participants were randomized to apply tretinoin 0.05% lotion to either the right or left side of the face before applying full-face foundation makeup. SETTING: Participants were enrolled at a single center in the United States. PARTICIPANTS: Female individuals aged 18 to 50 years who used facial foundation makeup ≥5 days per week were included. MEASUREMENTS: Investigator-assessed grading for foundation coverage and participant evaluations of makeup appearance were conducted at post-makeup application (Post-Makeup) and Hour 6 (6H) timepoints. Antera 3D® images were taken for skin texture roughness analysis and tolerability evaluations were performed at baseline, post-tretinoin application, Post-Makeup, and 6H timepoints. RESULTS: A total of 30 participants were enrolled and 29 completed the study. There were no significant differences between tretinoin treated and untreated sides for any outcomes of investigator-assessed grading of foundation (percentage coverage, blotchiness, overall coverage, skin tone evenness, visual smoothness). There was a small but statistically significant worsening in percent coverage at 6H versus Post-Makeup on the untreated side, but not the treated side. As rated by participants, even/full coverage and skin smoothness were significantly better on the tretinoin-lotion treated versus the untreated side. Three-dimensional imaging showed there were no significant differences in skin roughness between the treated and untreated sides. Participants reported overall satisfaction with the tretinoin lotion-treated side. CONCLUSION: Tretinoin 0.05% lotion did not interfere with facial makeup application or wearability and was well tolerated.

Keywords: Retinoid; acne; foundation; lotion; makeup; tretinoin.

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Conflict of interest statement

FUNDING:This study was funded by Ortho Dermatologics. DISCLOSURES:Bausch Health US, LLC is an affiliate of Bausch Health Companies Inc. Ortho Dermatologics is a division of Bausch Health US, LLC. Neal Bhatia has received honoraria and investigator grants from Bausch Health. Leon Kircik has acted as an investigator, advisor, speaker, and consultant for Ortho Dermatologics. Ava Shamban has received grants/ research support and/or consulting from Galderma, Merz, Endo, Brickell, B10, Revance, Teoxane, and Allergan. Varsha Bhatt and Radhakrishnan Pillai are employees of Bausch Health US, LLC and may hold stock and/or stock options in its parent company. Eric Guenin is an employee of Ortho Dermatologics and may hold stock and/or stock options in its parent company. Bausch Health US, LLC is an affiliate of Bausch Health Companies Inc. Ortho Dermatologics is a division of Bausch Health US, LLC.

Figures

FIGURE 1.
FIGURE 1.
Investigator-assessed clinical grading of foundation coverage scores (PP population). *P<0.05 for 6H vs. Post-Makeup timepoint on the untreated side. There were no significant differences between treated and untreated sides at either timepoint (Post-Makeup or 6H). Treated=tretinoin 0.05% lotion. 6H: 6 hours (±1 hour) Post-Makeup; Post-Makeup: post-makeup application; PP: per protocol; SD: standard deviation
FIGURE 2.
FIGURE 2.
Participant-assessed makeup scores (PP population). *P<0.05 for treated vs untreated sides at Post-Makeup timepoints. There were no significant differences between 6H and Post-Makeup for either treatment group (treated or untreated). Treated=tretinoin 0.05% lotion. 6H: 6 hours (±1 hour) Post-Makeup; Post-Makeup: post-makeup application; PP: per protocol; SD: standard deviation
FIGURE 3.
FIGURE 3.
VISIA imaging of skin texture roughness in standard light conditions. Photographs from a representative patient. Individual results may vary. 6H: 6 hours (±1 hour) Post-Makeup; Post-Makeup: post-makeup application; Post-Tretinoin: post-tretinoin lotion application
See this image and copyright information in PMC

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