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. 2020 Winter;13(Suppl1):S47-S52.

Lack of association between VEGF -2578C/A polymorphism and risk of colorectal cancer in an Iranian population

Sanaz Savabkar  1 , Neda Zali  1 , Mahrooyeh Hadizadeh  2 , Shabnam Tavangarroosta  1 , Chris Young  3 , Fateme Shojaeian  4 , Nastaran Ebrahimi  4 , Maziar Ashrafian Bonab  2 , Hamid Rezvani  4 , Farzaneh Shalileh  1 , Ehsan Nazemalhosseini-Mojarad  4
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Lack of association between VEGF -2578C/A polymorphism and risk of colorectal cancer in an Iranian population

Sanaz Savabkar et al. Gastroenterol Hepatol Bed Bench. 2020 Winter.

Abstract

Aim: Here, we evaluated the VEGF gene -2578C/A polymorphism as a potential susceptibility factor in colorectal cancer (CRC) occurrence amongst Iranian CRC patients.

Background: Vascular endothelial growth factor (VEGF) is a key regulatory factor in angiogenesis which plays essential roles in the development of malignancy in colorectal cancer (CRC), as the third most prevalent cancer worldwide.

Methods: VEGF -2578C/A polymorphism was evaluated in 200 CRC patients and 200 healthy control subjects via restriction fragment length polymorphism analysis.

Results: The frequencies of CC, AC and AA genotypes among CRC patients were 22.5%, 51% and 26.5%, respectively, with their respective genotype frequencies at 16%, 54% and 30% in control cohorts (P=0.247). The A allele frequency among the case group was 52% and for control group, it was 57%. C allele frequency in case and control groups was 48% and 43%, respectively (p=0.156). No significant association was observed (p=0.990) between this polymorphism and CRC stage.

Conclusion: Our findings provide limited support for the hypothesis that the -2578C/A VEGF are associated with increased risk of colorectal cancer in Iranian colorectal cancer patients and suggest instead that meta data studies, which have previously relied upon populations definitions such as 'Asian', should more specifically take into account country of origin when associating prognostic value to a given genotype.

Keywords: Angiogenesis; Colorectal cancer; Single nucleotide polymorphism; VEGF; Vascular endothelial growth factor.

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