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. 2020 Winter;13(Suppl1):S122-S127.

Prevalence of astrovirus, adenovirus, and sapovirus infections among Iranian children with acute gastroenteritis

Seyed Dawood Mousavi Nasab  1   2 , Fatemeh Zali  3 , Hooman Kaghazian  1   2 , Mohammad Reza Aghasadeghi  1   4 , Rajab Mardani  5 , Latif Gachkar  6 , Abbas Ahmadi Vasmehjani  7 , Nayebali Ahmadi  8 , Ali Ghasemzadeh  9
Affiliations

Prevalence of astrovirus, adenovirus, and sapovirus infections among Iranian children with acute gastroenteritis

Seyed Dawood Mousavi Nasab et al. Gastroenterol Hepatol Bed Bench. 2020 Winter.

Abstract

Aim: This study aimed to determine the prevalence of Human Astroviruses (HAstVs), enteric Adenoviruses (HAdVs), and Sapoviruses (SaVs) in acute diarrhea patients, as well as their relation to age, sex, and season.

Background: Acute gastroenteritis is one of the most common diseases affecting children <5 years old and viral agents with approximately >75% are the major causative agent of acute infectious diarrhea. After Rotavirus and Norovirus, the greater viral agents of acute gastroenteritis include HAstVs, HAdVs, and SaVs. To the best of our knowledge, there are sparse studies in Iran detecting at least three enteric viruses as causative agents of diarrhea simultaneously.

Methods: The sample was collected from children referring to pediatric medical centers in Tehran, Iran; they were tested for Astrovirus, enteric Adenovirus, and Sapovirus by conventional PCR method. The association of incidence of viral enteric agents was evaluated with age, sex and seasonal pattern in children <5 years old.

Results: The positive case number among acute gastroenteritis patients was 17/120 (14.1%). Patients ranged in age within 1-60 months, but 52.9% were aged ≤ 12 months. Males comprised the majority (70.6), and the male: female ratio was 2.4. HAstV was the most frequently detected virus (6.7%), while SaVs were detected only in 2.5% of cases. Mixed infections were not detected in these samples. The highest rate of HAstV was identified in winter (66.7%), HAdV in fall (66.7%), and SaV in winter (33.3%).

Conclusion: These findings underscore the importance of monitoring the epidemiology of HAstV, HAdV, and SaV as causative agents of viral diarrhea infections.

Keywords: Adenovirus; Astrovirus; Gastroenteritis virus; Polymerase chain reaction; Sapovirus.

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Figures

Figure 1
Figure 1
Detection of Human Astrovirus (HAstV), enteric Adenovirus (HAdV), and Sapovirus (SaV) by PCR. A) HAdV, B) HAstV, C) SaV. Ladder 1kb, NTC: Non-Template Control, PC: Positive Control
Figure 2
Figure 2
Distribution of the number of positive cases for enteric virus detection based on age groups
Figure 3
Figure 3
Distribution of the number of positive cases for enteric virus detection based on seasonality
See this image and copyright information in PMC

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