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Editorial
. 2021 Jan 20:7:644075.
doi: 10.3389/fmed.2020.644075. eCollection 2020.

Editorial: Interstitial Lung Disease in the Context of Systemic Disease: Pathophysiology, Treatment and Outcomes

Peter Korsten  1 , Maximilian F Konig  2 , Björn Tampe  1 , Mehdi Mirsaeidi  3
Affiliations
Editorial

Editorial: Interstitial Lung Disease in the Context of Systemic Disease: Pathophysiology, Treatment and Outcomes

Peter Korsten et al. Front Med (Lausanne). .
No abstract available

Keywords: autoimmune diseases; interstitial lung disease; myositis; rheumatoid arthritis; systemic sclerosis (scleroderma).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Overview of systemic diseases causing interstitial lung diseases (ILDs) and their associated antibodies. Conditions associated with a predominant NSIP pattern on HRCTs include Myositis-associated ILD (antisynthetase syndrome, anti-RO52 positive overlap myositis, or RP-ILD), Systemic Sclerosis, primary Sjögren's syndrome, and rarely, Systemic Lupus Erythematosus. In SSc, a UIP pattern may also be commonly found. RA-ILD frequently shows a UIP pattern and confers a guarded prognosis. An NSIP pattern may also be encountered on HRCTs. ACPA, anti-citrullinated peptide antibodies; ARS, aminoacyl-tRNA synthetase antibodies; CTD, connective tissue disease; HRCT, high-resolution computed tomography; MDA5; melanocyte-differentiation antigen 5; Myo, myositis; NSIP, non-specific interstitial pneumonia; Pm/Scl, polymyositis-scleroderma; pSS; primary Sjögren's syndrome; RA, rheumatoid arthritis; RF, rheumatoid factor; RNA Pol III, RNA polymerase III; RP, rapidly progressive; Scl70, topoisomerase I; SLE, systemic lupus erythematosus, Sm, Smith; SRP, signal recognition particle; SSc, systemic sclerosis; U1-snRNP, U1 small nuclear ribonucleoprotein; UIP, usual interstitial pneumonia. Created with BioRender.com.
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