Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Apr;108(4):496-511.
doi: 10.1007/s00223-020-00786-0. Epub 2021 Feb 14.

Traditional and Non-traditional Risk Factors for Osteoporosis in CKD

Hanne Skou Jørgensen  1   2 , Karel David  1   3 , Syazrah Salam  4   5 , Pieter Evenepoel  6   7 ; European Renal Osteodystrophy (EUROD) workgroup, an initiative of the CKD-MBD working group of the ERA-EDTA
Affiliations
Review

Traditional and Non-traditional Risk Factors for Osteoporosis in CKD

Hanne Skou Jørgensen et al. Calcif Tissue Int. 2021 Apr.

Abstract

Osteoporosis is a state of bone fragility with reduced skeletal resistance to trauma, and consequently increased risk of fracture. A wide range of conditions, including traditional risk factors, lifestyle choices, diseases and their treatments may contribute to bone fragility. It is therefore not surprising that the multi-morbid patient with chronic kidney disease (CKD) is at a particularly high risk. CKD is associated with reduced bone quantity, as well as impaired bone quality. Bone fragility in CKD is a composite of primary osteoporosis, accumulation of traditional and uremia-related risk factors, assaults brought on by systemic disease, and detrimental effects of drugs. Some risk factors are modifiable and represent potential targets for intervention. This review provides an overview of the heterogeneity of bone fragility in CKD.

Keywords: Bone density; Chronic kidney disease—mineral and bone disorder; Chronic renal insufficiency; Fracture; Kidney transplantation; Osteoporosis.

PubMed Disclaimer

References

    1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis and T (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA J Am Med Assoc 285:785–795. https://doi.org/10.1001/jama.285.6.785 - DOI
    1. Jadoul M, Albert JM, Akiba T et al (2006) Incidence and risk factors for hip or other bone fractures among hemodialysis patients in the Dialysis Outcomes and Practice Patterns Study. Kidney Int 70:1358–1366. https://doi.org/10.1038/sj.ki.5001754 - DOI - PubMed
    1. Tentori F, McCullough K, Kilpatrick RD et al (2014) High rates of death and hospitalization follow bone fracture among hemodialysis patients. Kidney Int 85:166–173. https://doi.org/10.1038/ki.2013.279;10.1038/ki.2013.279 - DOI - PubMed
    1. Yusuf AA, Hu Y, Chandler D et al (2020) Predictors of imminent risk of fracture in Medicare-enrolled men and women. Arch Osteoporos 15:120. https://doi.org/10.1007/s11657-020-00784-7 - DOI - PubMed - PMC
    1. Bowling CB, Bromfield SG, Colantonio LD et al (2016) Association of reduced eGFR and albuminuria with serious fall injuries among older adults. Clin J Am Soc Nephrol 11:1236–1243. https://doi.org/10.2215/CJN.11111015 - DOI - PubMed - PMC

Publication types

MeSH terms

LinkOut - more resources