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Review
. 2021 Apr;48(2):110-119.
doi: 10.1111/iji.12532. Epub 2021 Feb 15.

NK cells in antibody-mediated rejection - Key effector cells in microvascular graft damage

Megan A O'Neill  1 , Luis G Hidalgo  1
Affiliations
Review

NK cells in antibody-mediated rejection - Key effector cells in microvascular graft damage

Megan A O'Neill et al. Int J Immunogenet. 2021 Apr.

Abstract

Antibody-mediated rejection (ABMR) stands as the major limitation to long-term transplant outcome. The immunologic understanding of ABMR continues to progress and has identified natural killer (NK) cells as key effector cells promoting and coordinating the immune attack on the graft microvascular endothelium. This review discusses the current concepts outlining the different ways that allow for NK cell recognition of graft endothelial cells which includes antibody-dependent as well as independent processes.

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References

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