Harmonic optical microfiber Bragg grating immunosensor for the accelerative test of cardiac biomarker (cTn-I)

Abstract

Fiber-optic biosensor has shown tremendous promise in probing cardiac biomarkers label-free and in-operando. However, temperature cross-sensitivity is ubiquitously found and impedes further advances of the fiber-optic biosensors, especially for the scenario of rapid test at-body. In this study, we exploit a new regime that harnesses the harmonic resonances of a single microfiber Bragg grating to rule out the impact of the thermal noise. The reflections yielded by the harmonics can be engineered simultaneously at the two overriding optical wavebands, i.e., 1 μm and 1.55 μm, promising a remote acquisition of the sensing signals at patient by virtue of the Yb and/or Er-doped fiber amplifiers which are highly commercial. Furthermore, the functionality of the temperature-offset allows for the understanding of the biomolecular stimulating at the body temperature and thus facilitating the acceleration of the cardiac biomarker test. The proposed proof-of-concept enriches the arsenal of tools for fiber biosensors and enables a vista for the instant and in-vivo diagnosis of acute heart diseases.

Keywords: Acute myocardial infarction diagnosis; Cardiac troponin I; Harmonic bragg grating; Optical microfibers; Temperature compensation; Test acceleration.