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Review
. 2021 Mar;105(2):227-245.
doi: 10.1016/j.mcna.2020.09.009.

Rheumatic Complications of Immune Checkpoint Inhibitors

Nilasha Ghosh  1 , Anne R Bass  2
Affiliations
Review

Rheumatic Complications of Immune Checkpoint Inhibitors

Nilasha Ghosh et al. Med Clin North Am. 2021 Mar.

Abstract

Immune checkpoint inhibitors activate the immune system to combat cancer. In doing so, however, they can cause immune-related adverse events (irAEs), including rheumatic syndromes, such as inflammatory arthritis, polymyalgia rheumatica, and myositis. This article reviews rheumatic irAEs that may be encountered in the general medicine practice and provides guidance to support prompt recognition, referral, and treatment of these patients.

Keywords: Cancer; Disease-modifying antirheumatic drugs; Immune checkpoint inhibitors; Immune-related adverse events; Myositis; Polymyalgia rheumatica; Rheumatoid arthritis.

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Conflict of interest statement

Disclosure The authors have no commercial or financial conflicts of interest. N. Ghosh is supported by an NIH grant as a Master’s degree student in Clinical and Translational Investigation at Weill Cornell Medicine: NIH/NCATSUL1-TR-0023849.

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