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Review
. 2021 Jun:59:84-94.
doi: 10.1016/j.cytogfr.2021.01.008. Epub 2021 Feb 5.

Neurotrophic factors and their receptors in lung development and implications in lung diseases

Limor Rubin  1 , Collin T Stabler  2 , Adi Schumacher-Klinger  3 , Cezary Marcinkiewicz  4 , Peter I Lelkes  5 , Philip Lazarovici  6
Affiliations
Review

Neurotrophic factors and their receptors in lung development and implications in lung diseases

Limor Rubin et al. Cytokine Growth Factor Rev. 2021 Jun.

Abstract

Although lung innervation has been described by many studies in humans and rodents, the regulation of the respiratory system induced by neurotrophins is not fully understood. Here, we review current knowledge on the role of neurotrophins and the expression and function of their receptors in neurogenesis, vasculogenesis and during the embryonic development of the respiratory tree and highlight key implications relevant to respiratory diseases.

Keywords: Development; Lung; Neurotrophic factors; Receptors; Respiratory diseases.

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