Novel Musculoskeletal and Orthopedic Applications of ¹⁸F-Sodium Fluoride PET

William Y Raynor¹, Austin J Borja², Emily C Hancin³, Thomas J Werner⁴, Abass Alavi⁴, Mona-Elisabeth Revheim⁵

Affiliations

¹ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, PA 19129, USA.
² Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
³ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA.
⁴ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
⁵ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Sognsvannsveien 20, Oslo 0372, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Problemveien 7, Oslo 0315, Norway. Electronic address: monar@ous-hf.no.

PMID: 33589389
DOI: 10.1016/j.cpet.2020.12.006

Free article

Review

Novel Musculoskeletal and Orthopedic Applications of ¹⁸F-Sodium Fluoride PET

William Y Raynor et al. PET Clin. 2021 Apr.

Free article

. 2021 Apr;16(2):295-311.

doi: 10.1016/j.cpet.2020.12.006. Epub 2021 Feb 12.

Authors

William Y Raynor¹, Austin J Borja², Emily C Hancin³, Thomas J Werner⁴, Abass Alavi⁴, Mona-Elisabeth Revheim⁵

Affiliations

¹ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, PA 19129, USA.
² Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
³ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Lewis Katz School of Medicine at Temple University, 3500 North Broad Street, Philadelphia, PA 19140, USA.
⁴ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
⁵ Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Sognsvannsveien 20, Oslo 0372, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Problemveien 7, Oslo 0315, Norway. Electronic address: monar@ous-hf.no.

PMID: 33589389
DOI: 10.1016/j.cpet.2020.12.006

Abstract

PET imaging with ¹⁸F-sodium fluoride (NaF), combined with computed tomography or magnetic resonance, is a sensitive method of assessing bone turnover. Although NaF-PET is gaining popularity in detecting prostate cancer metastases to bone marrow, osseous changes represent secondary effects of cancer cell growth. PET tracers more appropriate for assessing prostate cancer metastases directly portray malignant activity and include ¹⁸F-fluciclovine and prostatic specific membrane antigen ligands. Recent studies investigating NaF-PET suggest utility in the assessment of benign musculoskeletal disorders. Emerging applications in assessing traumatic injuries, joint disease, back pain, orthopedic complications, and metabolic bone disease are discussed.

Keywords: Ankylosing spondylitis; Arthroplasty; Fracture; Infection; Osteoarthritis; Osteoporosis; Osteosarcoma; Temporomandibular disorder.

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Disclosure The authors have nothing to disclose.

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Novel Musculoskeletal and Orthopedic Applications of ¹⁸F-Sodium Fluoride PET

Affiliations

Novel Musculoskeletal and Orthopedic Applications of ¹⁸F-Sodium Fluoride PET

Authors

Affiliations

Abstract

Conflict of interest statement

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MeSH terms

Substances

LinkOut - more resources

Full Text Sources