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Observational Study
. 2021 Apr;41(4):743-748.
doi: 10.1038/s41372-021-00942-w. Epub 2021 Feb 15.

Association between early cerebral oxygenation and neurodevelopmental impairment or death in premature infants

Anup C Katheria  1 , Jacob Stout  2 , Ana L Morales  2 , Debra Poeltler  2 , Wade D Rich  2 , Jane Steen  2 , Shauna Nuzzo  2 , Neil Finer  2
Affiliations
Observational Study

Association between early cerebral oxygenation and neurodevelopmental impairment or death in premature infants

Anup C Katheria et al. J Perinatol. 2021 Apr.

Abstract

Objective: To assess the relationship between cerebral oxygenation in the first 72 h of life and neurodevelopmental impairment (NDI) at 2 years corrected age in former premature infants.

Study design: Prospective observational cohort study of 127 infants <32 weeks GA at birth with cerebral oxygenation monitoring using NIRS in the first 72 h of life.

Results: Using a threshold cutoff for cerebral hypoxia, infants with NDI or death had increased duration of hypoxia (4 vs 2.3%, p = 0.001), which was more pronounced in the 23-27 week subgroup (7.6 vs 3.2%, p < 0.001). Individual generalized estimating equations to adjust for repeated measures were modeled in this subgroup for the physiologic parameters including StO2. StO2 < 67% was a predictor for death or NDI (OR 2.75, 95% CI 1.006, 7.5132, p = 0.049).

Conclusion: An increased duration of cerebral hypoxia is associated with NDI or death in infants born <32 weeks GA.

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Conflict of interest statement

The authors declares no competing interests.

Figures

Fig. 1
Fig. 1. Consort diagram.
Progression of Subjects through screening, randomization and followup.
Fig. 2
Fig. 2. Physiological parameters presented over time in the 23–27 week cohort.
Cerebral oximetry (StO2), mean blood pressure (BP), peripheral oxygen saturation (SpO2) and heart rate (beats per minute) over 72 h (Panel A) and from 4 to 24 h of age (Panel B).
See this image and copyright information in PMC

Comment in

  • The clinical usefulness of cerebral oximetry.
    Greisen G, Dempsey E, Mimouni F. Greisen G, et al. J Perinatol. 2021 Apr;41(4):655-657. doi: 10.1038/s41372-021-00939-5. Epub 2021 Feb 11. J Perinatol. 2021. PMID: 33574583 No abstract available.

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