Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May;41(5):1025-1032.
doi: 10.1038/s41372-021-00948-4. Epub 2021 Feb 15.

Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC)

Kartikeya Makker  1 , Yuelong Ji  2 , Xiumei Hong  2 , Xiaobin Wang  2   3
Affiliations

Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC)

Kartikeya Makker et al. J Perinatol. 2021 May.

Abstract

Objective: Identify antenatal and neonatal factors associated with primary outcome of EUGR.

Methods: 1063 preterm infants from a subset of the BBC were included in this prospective cohort study. Regression analysis was carried out to evaluate associations of EUGR with antenatal factors and neonatal factors.

Results: 6.1% of the infants had in-utero growth restriction (IUGR) at birth and 21.7% of infants had EUGR. The adjusted odds ratio for EUGR status were significant for birth weight (OR 0.99, p = 0.00, CI 0.99-0.99), for GA at birth (OR 4.58, p = 0.00, CI 3.25-6.44), for PDA (OR 2.9, p = 0.02, CI 1.17-7.1), for NEC (OR 5.14, p = 0.012, CI 1.44-18.3) and for day of life of reaching full feeds (OR 1.04, p = 0.001, CI 1.01-1.06).

Conclusion: This study highlights important factors associated with EUGR. Additional studies are needed to gain further insight.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. Fenton TR, Chan HT, Madhu A, Griffin IJ, Hoyos A, Ziegler EE, et al. Preterm infant growth velocity calculations: a systematic review. Pediatrics. 2017;139. 10.1542/peds.2016-2045. - PubMed
    1. Fenton TR, Cormack B, Goldberg D, Nasser R, Alshaikh B, Eliasziw M, et al. ‘Extrauterine growth restriction’ and ‘postnatal growth failure’ are misnomers for preterm infants. J Perinatol. 2020. 10.1038/s41372-020-0658-5. - PubMed
    1. Radmacher PG, Looney SW, Rafail ST, Adamkin DH. Prediction of extrauterine growth retardation (EUGR) in VVLBW infants. J Perinatol. 2003;23:392–5. doi: 10.1038/sj.jp.7210947. - DOI - PubMed
    1. Dusick AM, Poindexter BB, Ehrenkranz RA, Lemons JA. Growth failure in the preterm infant: can we catch up? Semin Perinatol. 2003;27:302–10. doi: 10.1016/S0146-0005(03)00044-2. - DOI - PubMed
    1. Ordóñez-Díaz MD, Pérez-Navero JL, Flores-Rojas K, Olza-Meneses J, Muñoz-Villanueva MC, Aguilera-García CM, et al. Prematurity with extrauterine growth restriction increases the risk of higher levels of glucose, low-grade of inflammation and hypertension in prepubertal children. Front Pediatr. 2020;8:180. doi: 10.3389/fped.2020.00180. - DOI - PMC - PubMed

Publication types