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. 2021 May;31(5):589-592.
doi: 10.1038/s41422-020-00457-7. Epub 2021 Feb 15.

Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients

Lei Chen #  1   2 , Ghassan K Abou-Alfa #  3   4 , Bo Zheng #  1   2 , Jing-Feng Liu #  5 , Jian Bai #  6 , Lu-Tao Du #  7   8 , Yun-Song Qian #  9 , Rong Fan #  10 , Xiao-Long Liu #  5 , Lin Wu  11 , Jin-Lin Hou  12 , Hong-Yang Wang  13   14   15   16 ; PreCar Team
Collaborators, Affiliations

Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients

Lei Chen et al. Cell Res. 2021 May.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. The diagnostic value of HIFI method.
a ROC curves of HIFI method and AFP for HCC patients vs LC patients in the test set. b ROC curves of HIFI method for HCC patients vs LC patients in the 11 hospital-based validation + test sets. Hospitals 4, 9 and 10 were integrated into one due to their small size. c HIFI scores of all enrolled patients were shown. The cutoff value of HIFI score was 0.38. Upper: information of HCC patients. Lower: information of LC patients. d Proportions of positive and negative calling by HIFI method in LC patients with AFP < 20 μg/L, AFP 20–400 μg/L, and AFP > 400 μg/L, in the validation + test sets. e Proportions of positive and negative calling by HIFI method and AFP in LC patients with different ages, Child-Pugh stages, and HBV infection status in validation + test sets. f, g Proportions of positive and negative calling by HIFI method in HCC patients with different AFP and PIVKA-II levels in the validation + test sets. h–j Proportions of positive and negative calling by HIFI/AFP/PIVKA-II in HCC patients with different BCLC stages, AJCC stages, and tumor sizes in validation + test sets.
See this image and copyright information in PMC

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