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. 2021 May 1:290:129510.
doi: 10.1016/j.matlet.2021.129510. Epub 2021 Feb 11.

Preparation of cerium molybdates and their antiviral activity against bacteriophage Φ6 and SARS-CoV-2

Takuro Ito  1 , Kayano Sunada  2 , Takeshi Nagai  2 , Hitoshi Ishiguro  2 , Ryuichi Nakano  3 , Yuki Suzuki  3 , Akiyo Nakano  3 , Hisakazu Yano  3 , Toshihiro Isobe  1 , Sachiko Matsushita  1 , Akira Nakajima  1
Affiliations

Preparation of cerium molybdates and their antiviral activity against bacteriophage Φ6 and SARS-CoV-2

Takuro Ito et al. Mater Lett. .

Abstract

Two cerium molybdates (Ce2Mo3O12 and γ-Ce2Mo3O13) were prepared using either polymerizable complex method or hydrothermal process. The obtained powders were almost single-phase with different cerium valence. Both samples were found to have antiviral activity against bacteriophage Φ6. Especially, γ-Ce2Mo3O13 exhibited high antiviral activity against both bacteriophage Φ6 and SARS-CoV-2 coronavirus, which causes COVID-19. A synergetic effect of Ce and molybdate ion was inferred along with the specific surface area as key factors for antiviral activity.

Keywords: Antiviral; Cerium; Complex oxide; Coronavirus; Molybdate.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

None
Graphical abstract
Fig. 1
Fig. 1
XRD patterns (a) and SEM micrographs of prepared powders: (b) CMO(PC) and (c) CMO(HT).
Fig. 2
Fig. 2
Antiviral activities of prepared powders against Φ6 (a), with photographs showing the change of plaque number for Φ6 by CMO(HT) after 18 h: (b) control and (c) with CMO(HT). Antiviral activities of LMO and LCMO were referred from ref. .
Fig. 3
Fig. 3
Antiviral activity of CMO(HT), LCMO and MoO3 against coronavirus (a), with photographs showing the change of plaque number for coronavirus by CMO(HT) after 4 h: (b) control and (c) with CMO(HT).
See this image and copyright information in PMC

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