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Meta-Analysis
. 2021 Aug;59(4):813-836.
doi: 10.1007/s10528-021-10038-x. Epub 2021 Feb 15.

Vitamin D Receptor (VDR) Gene Polymorphisms and Risk of Coronary Artery Disease (CAD): Systematic Review and Meta-analysis

Samira Tabaei  1 , Morteza Motallebnezhad  2   3   4 , Seyedeh Samaneh Tabaee  5   6
Affiliations
Meta-Analysis

Vitamin D Receptor (VDR) Gene Polymorphisms and Risk of Coronary Artery Disease (CAD): Systematic Review and Meta-analysis

Samira Tabaei et al. Biochem Genet. 2021 Aug.

Abstract

Several studies have noted that vitamin D receptor (VDR) gene polymorphisms are involved in the susceptibility to Coronary artery disease (CAD). Nonetheless, the results have been inconclusive. Here, we performed the most up-to-date analysis of the association between VDR gene polymorphisms and risk of CAD. We conducted a comprehensive systematic search in the major electronic database, including Scopus and PubMed to look up for relevant studies evaluating the association between the VDR gene FokI (rs2228570), TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232) polymorphisms and susceptibility to CAD published before December 2019. The level of association between VDR gene polymorphisms and susceptibility to CAD in the polled analysis was calculated by odds ratio (OR) and the corresponding 95% confidence interval (CI). We found 14 articles containing 20,398 cases and 9371 controls. The analysis revealed that all genetic models in the FokI SNP were associated with increased risk of CAD. Furthermore, for the ApaI SNP, except recessive model, all other genetic models significantly increased the risk of CAD in the overall analysis. In addition, it was divulged that both FokI and ApaI SNPs were involved in increasing the risk of CAD in Asians and Europeans in a number of models. FokI and ApaI polymorphisms may confer a susceptibility genetic risk factor for development of CAD, particularly in the Asian population.

Keywords: Coronary artery disease; Genetic polymorphism; Meta-analysis; Vitamin D receptor.

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References

    1. Abu el Maaty MA, Hassanein SI, Gad MZ (2016) Genetic variation in vitamin D receptor gene (Fok1: rs2228570) is associated with risk of coronary artery disease. Biomarkers 21(1):68–72 - PubMed
    1. Alizadeh S et al (2017) Common variants of vitamin D receptor gene polymorphisms and susceptibility to coronary artery disease: a systematic review and meta-analysis. Lifestyle Genom 10(1–2):9–18
    1. Baeke F et al (2010) Vitamin D: modulator of the immune system. Curr Opin Pharmacol 10(4):482–496 - PubMed
    1. Bagheri-Hosseinabadi Z et al (2020) Vitamin D receptor (VDR) gene polymorphism and risk of rheumatoid arthritis (RA): systematic review and meta-analysis. Clin Rheumatol 21(1):263
    1. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics. https://doi.org/10.2307/2533446 - DOI - PubMed

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