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Review
. 2021 Aug;45(8):813-818.
doi: 10.1111/aor.13942. Epub 2021 Apr 1.

Aligned electrospun nerve conduits with electrical activity as a strategy for peripheral nerve regeneration

Vanessa Oliveira Castro  1 , Claudia Merlini  1   2
Affiliations
Review

Aligned electrospun nerve conduits with electrical activity as a strategy for peripheral nerve regeneration

Vanessa Oliveira Castro et al. Artif Organs. 2021 Aug.

Abstract

Peripheral nerve injuries affect the quality of life of people worldwide. Despite advances in materials and processing in recent decades, nerve repair remains a challenge. The autograft is considered the most effective nerve repair in cases of serious injuries in which direct suture is not applied. However, the autograft causes the loss of functionality of the donor site, and additionally, there is a limited availability of donor nerves. Nerve conduits emerge as an alternative to the autograft and nowadays some conduits are available for clinical use. Nevertheless, they still need to be optimized for better functional nerve response. This review proposes to analyze the use of aligned electrospun nerve conduits with electrical activity as a strategy to enhance a satisfactory nerve regeneration and functional recovery.

Keywords: conductive additive; conduit; electrospinning; peripheral nerve regeneration.

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References

REFERENCES

    1. Daly W, Zeugolis D, Windebank A, Yao L, Pandit A. A biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery. J R Soc Interface. 2011;9:202-21. https://doi.org/10.1098/rsif.2011.0438
    1. Arslantunali D, Dursun T, Yucel D, Hasirci N, Hasirci V. Peripheral nerve conduits: Technology update. Med Devices Evid Res. 2014;7:405-24. https://doi.org/10.2147/MDER.S59124
    1. Tuturov AO. The role of peripheral nerve surgery in a tissue reinnervation. Chin Neurosurg J. Published online 2019;1-5. https://doi.org/10.1097/PRS.0b013e31820063d4
    1. Chiono V, Tonda-Turo C. Trends in the design of nerve guidance channels in peripheral nerve tissue engineering. Prog Neurogibol. 2015;131:87-104. https://doi.org/10.1016/j.pneurobio.2015.06.001
    1. Dodla MC, Mukhatyar VJ, Bellamkonda RV. Peripheral Nerve Regeneration. Elsevier Inc. 2011. https://doi.org/10.1016/B978-0-12-381422-7.10056-2

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