Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr;36(4):852-856.
doi: 10.1002/mds.28515. Epub 2021 Feb 15.

Is Pre-Symptomatic Immunosuppression Protective in CSF1R-Related Leukoencephalopathy?

Philip W Tipton  1 , E Richard Stanley  2 , Violeta Chitu  2 , Zbigniew K Wszolek  3
Affiliations

Is Pre-Symptomatic Immunosuppression Protective in CSF1R-Related Leukoencephalopathy?

Philip W Tipton et al. Mov Disord. 2021 Apr.
No abstract available

Keywords: corticosteroid; microglia; CSF1R related leukoencephalopathy.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Top row: MRI (fluid attenuated inversion recovery) FLAIR sequence axial (A), T1-weighted sagittal (B) and coronal (C) images of a 43-year-old patient with CSF1R-related leukoencephalopathy. Bottom row: FLAIR sequence axial (D), T1-weighted sagittal (E) and coronal (F) images of the patient’s mother at 71 years of age. There is mild biparietal, and to a lesser extent, bifrontal cortical atrophy.
FIG. 2.
FIG. 2.
Illustration of immunosuppressive therapy administered to a 71-year-old carrier of a pathogenic mutation in the CSF1R gene.
See this image and copyright information in PMC

Comment in

References

    1. Nicholson AM, Baker MC, Finch NCA, et al. CSF1R mutations link POLD and HDLS as a single disease entity. Neurology 2013;80: 1033–1040. - PMC - PubMed
    1. Konno T, Yoshida K, Mizuno T, et al. Clinical and genetic characterization of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF1R mutation. Eur J Neurol 2017;24:37–45. - PMC - PubMed
    1. Rademakers R, Baker M, Nicholson AM, et al. Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nat Genet 2012;44: 200–205. - PMC - PubMed
    1. Konno T, Kasanuki K, Ikeuchi T, Dickson DW, Wszolek ZK. CSF1R-related leukoencephalopathy: a major player in primary microgliopathies. Neurology 2018;91:1092–1104. - PMC - PubMed
    1. Lakshmanan R, Adams ME, Lynch DS, et al. Redefining the phenotype of ALSP and AARS2 mutation-related leukodystrophy. Neurol Genet 2017;3:e135. - PMC - PubMed

Publication types