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Review
. 2021 May;47(5):1610-1623.
doi: 10.1111/jog.14710. Epub 2021 Feb 15.

The role of mitogen-activated protein kinase signaling pathway in endometriosis

Gizem Bora  1 , Aylin Yaba  1
Affiliations
Review

The role of mitogen-activated protein kinase signaling pathway in endometriosis

Gizem Bora et al. J Obstet Gynaecol Res. 2021 May.

Abstract

Aim: Endometriosis is an estrogen-dependent chronic inflammatory condition which causes pain, infertility, and predisposition for ovarian cancer. Endometriosis generates a unique microenvironment for survivability of endometriotic lesions which includes cell proliferation, differentiation, migration, and apoptosis. For these cellular activities, cascading activations of intracellular kinases are needed. Many kinase signaling pathways, IKKβ/NK-κB pathway, PI3K/AKT/mTOR, and the mitogen-activated protein kinase (MAPK) pathways (ERK1/2, p38, and JNK), are activated in endometriosis. In this review, we focus on the role of MAPK pathways in endometriosis.

Methods: To identify the role of MAP Kinase signaling pathway in endometriosis we searched the Pubmed database using the search terms in various combinations "endometriosis," "endometrium," "ovary," "MAPK pathway," "ERK pathway," "p38 pathway," "JNK pathway," "estrogen," and "progesterone."

Results: According to the current literature, MAPK signaling pathway has various roles in generating microenvironment and survival of endometriosis. Abnormal MAPK activation in migration, implantation, growth, invasion into the pelvic structures, proliferation, and apoptosis leads to the form of endometriosis and to worsen the condition in patients with endometriosis.

Conclusion: To further investigations on the effective and long-term endometriosis treatment, MAPK signaling pathways may be targeted. Molecular mechanism of MAPK signaling pathway in endometriosis should be more deeply understood and clinical trials should be more commonly performed for possible new endometriosis treatments to improve fertility and rescue endometriosis irreversibly.

Keywords: MAPK kinases; endometriosis; female reproductivity.

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References

    1. Roach MK, Andreotti RF. The Normal female pelvis. Clin Obstet Gynecol. 2017;60(1):3-10.
    1. Wray S, Prendergast C. The myometrium: from excitation to contractions and labour. Adv Exp Med Biol. 2019;1124:233-63.
    1. Maybin JA, Critchley HO. Menstrual physiology: implications for endometrial pathology and beyond. Hum Reprod Update. 2015;21(6):748-61.
    1. Marquardt RM, Kim TH, Shin JH, Jeong JW. Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis? Int J Mol Sci. 2019;20(15):3822.
    1. Mihm M, Gangooly S, Muttukrishna S. The normal menstrual cycle in women. Anim Reprod Sci. 2011;124(3-4):229-36.

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