The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness

Craig M Coopersmith¹, Massimo Antonelli², Seth R Bauer³, Clifford S Deutschman^{4

5}, Laura E Evans⁶, Ricard Ferrer⁷, Judith Hellman⁸, Sameer Jog⁹, Jozef Kesecioglu¹⁰, Niranjan Kissoon¹¹, Ignacio Martin-Loeches^{12

13}, Mark E Nunnally¹⁴, Hallie C Prescott¹⁵, Andrew Rhodes¹⁶, Daniel Talmor¹⁷, Pierre Tissieres¹⁸, Daniel De Backer¹⁹

Affiliations

¹ Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, GA.
² Department of Anesthesiology Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Italy.
³ Department of Pharmacy, Cleveland Clinic, Cleveland, OH.
⁴ Department of Pediatrics, Cohen Children's Medical center, Northwell Health, New Hyde Park, NY.
⁵ Feinstein Institute for Medical Research/Elmezzi Graduate School of Molecular Medicine, Manhasset, NY.
⁶ Department of Medicine, University of Washington, Seattle, WA.
⁷ Department of Intensive Care, SODIR-VHIR Research Group, Vall d'Hebron University Hospital, Barcelona, Spain.
⁸ Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
⁹ Department of Intensive Care Medicine, Deenanath Mangeshkar Hospital, Pune, India.
¹⁰ Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
¹¹ Department of Pediatrics and Emergency Medicine, University of British Columbia, Vancouver, BC, Canada.
¹² Multidisciplinary Intensive Care Research Organization (MICRO), Department of Intensive Care Medicine, St. James's University Hospital, Trinity Centre for Health Sciences, Dublin, Ireland.
¹³ Hospital Clinic, IDIBAPS, Universided de Barcelona, CIBERes, Barcelona, Spain.
¹⁴ Departments of Anesthesiology, Perioperative Care and Pain Medicine, Neurology, Surgery and Medicine, New York University, New York, NY.
¹⁵ Department of Medicine, University of Michigan and VA Center for Clinical Management Research, Ann Arbor, MI.
¹⁶ St George's University Hospitals NHS Foundation Trust and St George's University of London, London, United Kingdom.
¹⁷ Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
¹⁸ Pediatric Intensive Care, AP-HP Paris Saclay University, Le Kremlin-Bicetre and Institute of Integrative Biology of the Cell, CNRS, CEA, Paris-Saclay University, Gif-sur-Yvette, France.
¹⁹ Chirec Hospitals, Université Libre de Bruxelles, Brussels, Belgium.

PMID: 33591008
DOI: 10.1097/CCM.0000000000004895

The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness

Craig M Coopersmith et al. Crit Care Med. 2021.

. 2021 Apr 1;49(4):598-622.

doi: 10.1097/CCM.0000000000004895.

Authors

Affiliations

¹ Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, GA.
² Department of Anesthesiology Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Italy.
³ Department of Pharmacy, Cleveland Clinic, Cleveland, OH.
⁴ Department of Pediatrics, Cohen Children's Medical center, Northwell Health, New Hyde Park, NY.
⁵ Feinstein Institute for Medical Research/Elmezzi Graduate School of Molecular Medicine, Manhasset, NY.
⁶ Department of Medicine, University of Washington, Seattle, WA.
⁷ Department of Intensive Care, SODIR-VHIR Research Group, Vall d'Hebron University Hospital, Barcelona, Spain.
⁸ Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
⁹ Department of Intensive Care Medicine, Deenanath Mangeshkar Hospital, Pune, India.
¹⁰ Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
¹¹ Department of Pediatrics and Emergency Medicine, University of British Columbia, Vancouver, BC, Canada.
¹² Multidisciplinary Intensive Care Research Organization (MICRO), Department of Intensive Care Medicine, St. James's University Hospital, Trinity Centre for Health Sciences, Dublin, Ireland.
¹³ Hospital Clinic, IDIBAPS, Universided de Barcelona, CIBERes, Barcelona, Spain.
¹⁴ Departments of Anesthesiology, Perioperative Care and Pain Medicine, Neurology, Surgery and Medicine, New York University, New York, NY.
¹⁵ Department of Medicine, University of Michigan and VA Center for Clinical Management Research, Ann Arbor, MI.
¹⁶ St George's University Hospitals NHS Foundation Trust and St George's University of London, London, United Kingdom.
¹⁷ Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
¹⁸ Pediatric Intensive Care, AP-HP Paris Saclay University, Le Kremlin-Bicetre and Institute of Integrative Biology of the Cell, CNRS, CEA, Paris-Saclay University, Gif-sur-Yvette, France.
¹⁹ Chirec Hospitals, Université Libre de Bruxelles, Brussels, Belgium.

PMID: 33591008
DOI: 10.1097/CCM.0000000000004895

Abstract

Objectives: To identify research priorities in the management, pathophysiology, and host response of coronavirus disease 2019 in critically ill patients.

Design: The Surviving Sepsis Research Committee, a multiprofessional group of 17 international experts representing the European Society of Intensive Care Medicine and Society of Critical Care Medicine, was virtually convened during the coronavirus disease 2019 pandemic. The committee iteratively developed the recommendations and subsequent document.

Methods: Each committee member submitted a list of what they believed were the most important priorities for coronavirus disease 2019 research. The entire committee voted on 58 submitted questions to determine top priorities for coronavirus disease 2019 research.

Results: The Surviving Sepsis Research Committee provides 13 priorities for coronavirus disease 2019. Of these, the top six priorities were identified and include the following questions: 1) Should the approach to ventilator management differ from the standard approach in patients with acute hypoxic respiratory failure?, 2) Can the host response be modulated for therapeutic benefit?, 3) What specific cells are directly targeted by severe acute respiratory syndrome coronavirus 2, and how do these cells respond?, 4) Can early data be used to predict outcomes of coronavirus disease 2019 and, by extension, to guide therapies?, 5) What is the role of prone positioning and noninvasive ventilation in nonventilated patients with coronavirus disease?, and 6) Which interventions are best to use for viral load modulation and when should they be given?

Conclusions: Although knowledge of both biology and treatment has increased exponentially in the first year of the coronavirus disease 2019 pandemic, significant knowledge gaps remain. The research priorities identified represent a roadmap for investigation in coronavirus disease 2019.

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Conflict of interest statement

Dr. Deutschman is past president of the Society of Critical Care Medicine, is a scientific editor for Critical Care Medicine, and is a consultant for Enlivex and Lowell Therapeutics; his institution received funding from National Institute of General Medical Sciences; he received funding from the Society of Critical Care Medicine, Elsevier, Enlivex, Sage Therapeutics, and La Jolla Pharmaceuticals; and he received support for article research from the National Institutes of Health (NIH). Dr. Evans disclosed that she serves as the cochair of the Surviving Sepsis Committee and as the adult Surviving Sepsis Campaign Guidelines for the management of sepsis and septic shock. Dr. Ferrer received funding from MSD, Pfizer, and Gilead. Dr. Kesecioglu is president of the European Society of Intensive Care Medicine. Dr. Kissoon is the pediatrics guidelines cochair of the Surviving Sepsis Committee. Dr. Martin-Loeches received honoraria from MSD, Gilead, and Aspen. Dr. Nunnally is Treasurer of the Society of Critical Care Anesthesiologists. Dr. Prescott is the sepsis lead for a Michigan statewide sepsis quality improvement initiative sponsored by Blue Cross Blue Shield of Michigan, and his institution received funding from Agency for Healthcare Research and Quality, the Department of Veterans Affairs, and the NIH, and she disclosed government work. Dr. Rhodes is the adult guidelines cochair of the Surviving Sepsis Committee and a member of the Executive Committee. Dr. Talmor received speaking fees from Hamilton Medical, Clew, and Mindray. Dr. Tissieres is president of the European Society of Pediatric and Neonatal Intensive Care, is the pediatrics guidelines cochair of the Surviving Sepsis Committee, and has received consulting fees or research grant from Baxter, bioMerieux, Sanofi. Dr. DeBacker is past president of the European Society of Intensive Care Medicine and has received consulting fees from Fresenius Kabi. The remaining authors have disclosed that they do not have any potential conflicts of interest.

References

1. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). 2020. Available at: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594... . Accessed November 25, 2020
1. Armstrong RA, Kane AD, Cook TM: Decreasing mortality rates in ICU during the COVID-19 pandemic. Anaesthesia 2020 Aug 10. [online ahead of print]
1. Auld SC, Caridi-Scheible M, Robichaux C, et al.: Declines in mortality over time for critically ill adults with coronavirus disease 2019. Crit Care Med 2020; 48:e1382–e1384
1. NIH COVID-19 Treatment Guidelines: 2020. Available at: https://www.covid19treatmentguidelines.nih.gov/ . Accessed November 25, 2020
1. World Health Organization: Therapeutics and COVID-19: living guideline. 2020. Available at: https://www.who.int/publications/i/item/therapeutics-and-covid-19-living... . Accessed November 25, 2020

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The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness

Affiliations

The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness

Authors

Affiliations

Abstract

Conflict of interest statement

References

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical