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. 1988 Feb;93(2):349-56.
doi: 10.1111/j.1476-5381.1988.tb11441.x.

Central inhibition by gamma-aminobutyric acid of the release of vasopressin by carbachol in the rat

H S Chowdrey  1 , G W Bisset
Affiliations

Central inhibition by gamma-aminobutyric acid of the release of vasopressin by carbachol in the rat

H S Chowdrey et al. Br J Pharmacol. 1988 Feb.

Abstract

1. gamma-Aminobutyric acid (GABA) inhibited the antidiuretic response and the increased urinary excretion of vasopressin produced by carbachol when both drugs were injected into a lateral cerebral ventricle (i.c.v.) in the water-loaded rat under ethanol anaesthesia. 2. The inhibitory effect of GABA was mimicked by muscimol and 3-amino-1-propane sulphonic acid (3-APS) and blocked by bicuculline. 3. GABA injected i.v. or into the cisterna magna (i.cist.) did not inhibit the release of vasopressin by carbachol injected i.c.v. 4. The results suggest a role for GABA as a putative inhibitory transmitter in the hypothalamo-neurohypophysial system, acting directly on the supraoptic or paraventricular nuclei in the anterior hypothalamus.

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