Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

doi:10.1007/s00401-021-02271-w

Comment

. 2021 Apr;141(4):623-624.

doi: 10.1007/s00401-021-02271-w. Epub 2021 Feb 16.

Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

Laxmi Kirola^{1

2}, John P Budde^{1

2

3}, Fengxian Wang^{1

2

3}, Joanne Norton^{1

2

3}, John C Morris^{2

4}; NIA-LOAD family study group, NCRAD, the ADSP project; Carlos Cruchaga^{1

2

3}, Maria Victoria Fernández^{5

6

7}

Affiliations

¹ Department Psychiatry, Washington University School of Medicine (WUSM), 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.
² Hope Center for Neurological Disorders, WUSM, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA.
³ NeuroGenomics and Informatics Center, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, USA.
⁴ Knight Alzheimer Disease Research Center, WUSM, 4488 Forest Park Ave, St. Louis, MO, 63108, USA.
⁵ Department Psychiatry, Washington University School of Medicine (WUSM), 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA. fernandezv@wustl.edu.
⁶ Hope Center for Neurological Disorders, WUSM, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA. fernandezv@wustl.edu.
⁷ NeuroGenomics and Informatics Center, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, USA. fernandezv@wustl.edu.

PMID: 33591372
PMCID: PMC7952336
DOI: 10.1007/s00401-021-02271-w

Comment

Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

Laxmi Kirola et al. Acta Neuropathol. 2021 Apr.

. 2021 Apr;141(4):623-624.

doi: 10.1007/s00401-021-02271-w. Epub 2021 Feb 16.

Authors

Affiliations

¹ Department Psychiatry, Washington University School of Medicine (WUSM), 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA.
² Hope Center for Neurological Disorders, WUSM, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA.
³ NeuroGenomics and Informatics Center, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, USA.
⁴ Knight Alzheimer Disease Research Center, WUSM, 4488 Forest Park Ave, St. Louis, MO, 63108, USA.
⁵ Department Psychiatry, Washington University School of Medicine (WUSM), 660 S. Euclid Ave. B8134, St. Louis, MO, 63110, USA. fernandezv@wustl.edu.
⁶ Hope Center for Neurological Disorders, WUSM, 660 S. Euclid Ave. B8111, St. Louis, MO, 63110, USA. fernandezv@wustl.edu.
⁷ NeuroGenomics and Informatics Center, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO, USA. fernandezv@wustl.edu.

PMID: 33591372
PMCID: PMC7952336
DOI: 10.1007/s00401-021-02271-w

No abstract available

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Comment in

Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.
Cacace R, Van Broeckhoven C. Cacace R, et al. Acta Neuropathol. 2021 Apr;141(4):625-626. doi: 10.1007/s00401-021-02277-4. Epub 2021 Feb 16. Acta Neuropathol. 2021. PMID: 33591373 Free PMC article. No abstract available.

Comment on

Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample.
Rademakers R, Cruts M, Sleegers K, Dermaut B, Theuns J, Aulchenko Y, Weckx S, De Pooter T, Van den Broeck M, Corsmit E, De Rijk P, Del-Favero J, van Swieten J, van Duijn CM, Van Broeckhoven C. Rademakers R, et al. Am J Hum Genet. 2005 Oct;77(4):643-52. doi: 10.1086/491749. Epub 2005 Aug 30. Am J Hum Genet. 2005. PMID: 16175510 Free PMC article.

Cited by

Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice.
Lin L, Petralia RS, Holtzclaw L, Wang YX, Abebe D, Hoffman DA. Lin L, et al. Neurobiol Dis. 2022 Nov;174:105887. doi: 10.1016/j.nbd.2022.105887. Epub 2022 Oct 6. Neurobiol Dis. 2022. PMID: 36209950 Free PMC article.
Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.
Cacace R, Van Broeckhoven C. Cacace R, et al. Acta Neuropathol. 2021 Apr;141(4):625-626. doi: 10.1007/s00401-021-02277-4. Epub 2021 Feb 16. Acta Neuropathol. 2021. PMID: 33591373 Free PMC article. No abstract available.

References

1. Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, Duijn V, et al. The Alzheimer’s disease sequencing project: study design and sample selection. Neurol Genet. 2017;3(5):e194. doi: 10.1212/NXG.0000000000000194. - DOI - PMC - PubMed
1. Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, et al. Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability. Acta Neuropathol. 2019;137(6):901–918. doi: 10.1007/s00401-019-01976-3. - DOI - PMC - PubMed
1. Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015;4:7. doi: 10.1186/s13742-015-0047-8. - DOI - PMC - PubMed
1. Fernández MV, Black K, Carrell D, Saef B, Budde J, Deming Y, et al. SORL1 variants across Alzheimer’s disease European American cohorts. Eur J Hum Genet. 2016;24(12):1828–1830. doi: 10.1038/ejhg.2016.122. - DOI - PMC - PubMed
1. Fernández MV, Budde J, Del-Aguila JL, Ibañez L, Deming Y, Harari O, et al. Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease. Front Neurosci. 2018;12:209. doi: 10.3389/fnins.2018.00209. - DOI - PMC - PubMed

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[1] Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, Duijn V, et al. The Alzheimer’s disease sequencing project: study design and sample selection. Neurol Genet. 2017;3(5):e194. doi: 10.1212/NXG.0000000000000194. - DOI - PMC - PubMed

[2] Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, Duijn V, et al. The Alzheimer’s disease sequencing project: study design and sample selection. Neurol Genet. 2017;3(5):e194. doi: 10.1212/NXG.0000000000000194. - DOI - PMC - PubMed

[3] Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, et al. Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability. Acta Neuropathol. 2019;137(6):901–918. doi: 10.1007/s00401-019-01976-3. - DOI - PMC - PubMed

[4] Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, et al. Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability. Acta Neuropathol. 2019;137(6):901–918. doi: 10.1007/s00401-019-01976-3. - DOI - PMC - PubMed

[5] Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015;4:7. doi: 10.1186/s13742-015-0047-8. - DOI - PMC - PubMed

[6] Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015;4:7. doi: 10.1186/s13742-015-0047-8. - DOI - PMC - PubMed

[7] Fernández MV, Black K, Carrell D, Saef B, Budde J, Deming Y, et al. SORL1 variants across Alzheimer’s disease European American cohorts. Eur J Hum Genet. 2016;24(12):1828–1830. doi: 10.1038/ejhg.2016.122. - DOI - PMC - PubMed

[8] Fernández MV, Black K, Carrell D, Saef B, Budde J, Deming Y, et al. SORL1 variants across Alzheimer’s disease European American cohorts. Eur J Hum Genet. 2016;24(12):1828–1830. doi: 10.1038/ejhg.2016.122. - DOI - PMC - PubMed

[9] Fernández MV, Budde J, Del-Aguila JL, Ibañez L, Deming Y, Harari O, et al. Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease. Front Neurosci. 2018;12:209. doi: 10.3389/fnins.2018.00209. - DOI - PMC - PubMed

[10] Fernández MV, Budde J, Del-Aguila JL, Ibañez L, Deming Y, Harari O, et al. Evaluation of gene-based family-based methods to detect novel genes associated with familial late onset Alzheimer disease. Front Neurosci. 2018;12:209. doi: 10.3389/fnins.2018.00209. - DOI - PMC - PubMed

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Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

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Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

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