Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

doi:10.1007/s00401-021-02277-4

Comment

. 2021 Apr;141(4):625-626.

doi: 10.1007/s00401-021-02277-4. Epub 2021 Feb 16.

Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

Rita Cacace^{1

2}, Christine Van Broeckhoven^{3

4}

Affiliations

¹ VIB Center for Molecular Neurology, Antwerp, Belgium.
² Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
³ VIB Center for Molecular Neurology, Antwerp, Belgium. christine.vanbroeckhoven@uantwerpen.vib.be.
⁴ Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. christine.vanbroeckhoven@uantwerpen.vib.be.

PMID: 33591373
PMCID: PMC7952278
DOI: 10.1007/s00401-021-02277-4

Comment

Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

Rita Cacace et al. Acta Neuropathol. 2021 Apr.

. 2021 Apr;141(4):625-626.

doi: 10.1007/s00401-021-02277-4. Epub 2021 Feb 16.

Authors

Rita Cacace^{1

2}, Christine Van Broeckhoven^{3

4}

Affiliations

¹ VIB Center for Molecular Neurology, Antwerp, Belgium.
² Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
³ VIB Center for Molecular Neurology, Antwerp, Belgium. christine.vanbroeckhoven@uantwerpen.vib.be.
⁴ Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. christine.vanbroeckhoven@uantwerpen.vib.be.

PMID: 33591373
PMCID: PMC7952278
DOI: 10.1007/s00401-021-02277-4

No abstract available

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Comment on

Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample.
Rademakers R, Cruts M, Sleegers K, Dermaut B, Theuns J, Aulchenko Y, Weckx S, De Pooter T, Van den Broeck M, Corsmit E, De Rijk P, Del-Favero J, van Swieten J, van Duijn CM, Van Broeckhoven C. Rademakers R, et al. Am J Hum Genet. 2005 Oct;77(4):643-52. doi: 10.1086/491749. Epub 2005 Aug 30. Am J Hum Genet. 2005. PMID: 16175510 Free PMC article.
Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population.
Kirola L, Budde JP, Wang F, Norton J, Morris JC; NIA-LOAD family study group, NCRAD, the ADSP project; Cruchaga C, Fernández MV. Kirola L, et al. Acta Neuropathol. 2021 Apr;141(4):623-624. doi: 10.1007/s00401-021-02271-w. Epub 2021 Feb 16. Acta Neuropathol. 2021. PMID: 33591372 Free PMC article. No abstract available.

Cited by

Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice.
Lin L, Petralia RS, Holtzclaw L, Wang YX, Abebe D, Hoffman DA. Lin L, et al. Neurobiol Dis. 2022 Nov;174:105887. doi: 10.1016/j.nbd.2022.105887. Epub 2022 Oct 6. Neurobiol Dis. 2022. PMID: 36209950 Free PMC article.

References

1. Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, et al. Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability. Acta Neuropathol. 2019;137:901–918. doi: 10.1007/s00401-019-01976-3. - DOI - PMC - PubMed
1. Cruts M, Theuns J, Van Broeckhoven C. Locus-specific mutation databases for neurodegenerative brain diseases. Hum Mutat. 2012;33:1340–1344. doi: 10.1002/humu.22117. - DOI - PMC - PubMed
1. Kirola L, Budde JP, Wang F, Norton J, Morris JC, NIA-LOAD family study group et al. (2021) Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer’s disease in the European American population. Acta Neuropathol Accepted - PMC - PubMed
1. Lin L, Petralia RS, Lake R, Wang YX, Hoffman DA. A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Acta Neuropathol Commun. 2020;8:197. doi: 10.1186/s40478-020-01065-7. - DOI - PMC - PubMed
1. Pottier C, Ren Y, Perkerson RB, 3rd, Baker M, Jenkins GD, van Blitterswijk M, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol. 2019 doi: 10.1007/s00401-019-01962-9. - DOI - PMC - PubMed

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[1] Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, et al. Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability. Acta Neuropathol. 2019;137:901–918. doi: 10.1007/s00401-019-01976-3. - DOI - PMC - PubMed

[2] Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, et al. Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability. Acta Neuropathol. 2019;137:901–918. doi: 10.1007/s00401-019-01976-3. - DOI - PMC - PubMed

[3] Cruts M, Theuns J, Van Broeckhoven C. Locus-specific mutation databases for neurodegenerative brain diseases. Hum Mutat. 2012;33:1340–1344. doi: 10.1002/humu.22117. - DOI - PMC - PubMed

[4] Cruts M, Theuns J, Van Broeckhoven C. Locus-specific mutation databases for neurodegenerative brain diseases. Hum Mutat. 2012;33:1340–1344. doi: 10.1002/humu.22117. - DOI - PMC - PubMed

[5] Kirola L, Budde JP, Wang F, Norton J, Morris JC, NIA-LOAD family study group et al. (2021) Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer’s disease in the European American population. Acta Neuropathol Accepted - PMC - PubMed

[6] Kirola L, Budde JP, Wang F, Norton J, Morris JC, NIA-LOAD family study group et al. (2021) Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer’s disease in the European American population. Acta Neuropathol Accepted - PMC - PubMed

[7] Lin L, Petralia RS, Lake R, Wang YX, Hoffman DA. A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Acta Neuropathol Commun. 2020;8:197. doi: 10.1186/s40478-020-01065-7. - DOI - PMC - PubMed

[8] Lin L, Petralia RS, Lake R, Wang YX, Hoffman DA. A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Acta Neuropathol Commun. 2020;8:197. doi: 10.1186/s40478-020-01065-7. - DOI - PMC - PubMed

[9] Pottier C, Ren Y, Perkerson RB, 3rd, Baker M, Jenkins GD, van Blitterswijk M, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol. 2019 doi: 10.1007/s00401-019-01962-9. - DOI - PMC - PubMed

[10] Pottier C, Ren Y, Perkerson RB, 3rd, Baker M, Jenkins GD, van Blitterswijk M, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol. 2019 doi: 10.1007/s00401-019-01962-9. - DOI - PMC - PubMed

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Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

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Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population

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