Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May;62(2):e178-e191.
doi: 10.1111/ajd.13535. Epub 2021 Feb 16.

Congenital melanocytic naevi: An up-to-date overview

Affiliations
Review

Congenital melanocytic naevi: An up-to-date overview

Banu Farabi et al. Australas J Dermatol. 2021 May.

Abstract

Congenital melanocytic naevi are hamartomas of the neuroectoderm caused by genetic mosaicism. Congenital melanocytic naevi are seen in 1-6% of all live births and commonly classified based on the projected size in adults. Congenital melanocytic naevi appear in different colours, shapes, and sizes, and occasionally present with complications. In this review, we sought to evaluate congenital melanocytic naevi, their clinical, dermatoscopic, and reflectance confocal microscopic features, behavioural pattern over time, new trends in classification, underlying genetic factors and their influence on clinical manifestations and management, associated risks, complications, magnetic resonance imaging findings and their management in the light of recent literature.

Keywords: classification; congenital melanocytic naevi; dermatoscopy; dermoscopy; follow-up; genetics; management; neurocutaneous melanocytosis; reflectance confocal microscopy; surgery; treatment.

PubMed Disclaimer

References

    1. Rosendahl CO, Grant-Kels JM, Que SK. Dysplastic nevus: Fact and fiction. J. Am. Acad. Dermatol. 2015; 73: 507-12.
    1. Barnhill RL, Fleischli M. Histologic features of congenital melanocytic nevi in infants 1 year of age or younger. J. Am. Acad. Dermatol. 1995; 33(5 Pt 1): 780-5.
    1. Bauer J, Curtin JA, Pinkel D et al. Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations. J. Invest. Dermatol. 2007; 127: 179-82.
    1. Salgado CM, Basu D, Nikiforova M et al. BRAF mutations are also associated with neurocutaneous melanocytosis and large/giant congenital melanocytic nevi. Pediatr. Dev. Pathol. 2015; 18: 1-9.
    1. Ingordo V, Gentile C, Iannazzone SS et al. Congenital melanocytic nevus: an epidemiologic study in italy. Dermatology 2007; 214: 227-30.

Substances

Supplementary concepts

LinkOut - more resources