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. 2021 Feb 11;13(4):5748-5803.
doi: 10.18632/aging.202502. Epub 2021 Feb 11.

Global incidence and mortality of breast cancer: a trend analysis

Junjie Huang  1 , Paul Sf Chan  1 , Veeleah Lok  1 , Xiao Chen  1 , Hanyue Ding  1 , Yinzi Jin  2 , Jinqiu Yuan  3 , Xiang-Qian Lao  1   4 , Zhi-Jie Zheng  2 , Martin Cs Wong  1   2   5
Affiliations

Global incidence and mortality of breast cancer: a trend analysis

Junjie Huang et al. Aging (Albany NY). .

Abstract

This study aimed to evaluate the global incidence and mortality trends of breast cancer among females by region and age in the past decade. We retrieved country-specific incidence and mortality data from the Global Cancer Observatory up to 2018 and Cancer Incidence in Five Continents volumes I-XI, the Nordic Cancer Registries, the Surveillance, Epidemiology, and End Results, and WHO mortality database up to 2016. The temporal patterns were using Average Annual Percent Change (AAPC) with the 95% confidence interval (CI) by joinpoint regression analysis. Most countries showed an increasing trend in incidence. For the older population aged ≥ 50 years, Japan (5.63, 4.90-6.36), Slovakia (3.63, 3.03-4.22), China (2.86, 2.00-3.72) reported the most prominent increase. For young females (<50 years), Japan (AAPC=3.81, 95% CI=2.71-4.93), Germany (AAPC=2.60, 95% CI=1.41-3.81) and Slovakia (1.91, 1.13-2.69) reported the most drastic rise. Similarly, 12 countries showed an incidence increase among women aged <40 years. As for mortality, the Philippines (4.36, 3.65-5.07), Thailand (4.35, 3.12-5.59), Colombia (0.75, 0.08-1.42), and Brazil (0.44, 0.19-0.68) reported a significant increase. The disease burden of breast cancer showed an increasing trend in a large number of populations. More preventive efforts are recommended for these countries. Further research should explore the underlying reasons for these epidemiological trends.

Keywords: breast cancer; epidemiology; incidence; mortality; trend analysis.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Global estimated incidence of breast cancer in 2018, females, all ages.
Figure 2
Figure 2
Global estimated mortality of breast cancer in 2018, females, all ages.
Figure 3
Figure 3
The AAPC of the incidence of breast cancer in individuals aged 0-85+ years.
Figure 4
Figure 4
The AAPC of the mortality of breast cancer in individuals aged 0-85+ years.
Figure 5
Figure 5
The AAPC of the incidence of breast cancer in individuals aged ≥ 50 years.
Figure 6
Figure 6
The AAPC of the incidence of breast cancer in individuals aged < 50 years.
Figure 7
Figure 7
The AAPC of the incidence of breast cancer in individuals aged < 40 years.
See this image and copyright information in PMC

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