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. 2021 Feb 5;100(5):e23946.
doi: 10.1097/MD.0000000000023946.

Effect of acupoint catgut embedding in chronic fatigue syndrome patients: A protocol for systematic review and meta-analysis

Mei-Lin Zhang  1 , Hong-Juan Fu  2   3 , Yong Tang  1 , Zhen-Guo Luo  1 , Jian-Yong Li  1 , Rui Li  1
Affiliations

Effect of acupoint catgut embedding in chronic fatigue syndrome patients: A protocol for systematic review and meta-analysis

Mei-Lin Zhang et al. Medicine (Baltimore). .

Abstract

Background: Chronic fatigue syndrome (CFS) is a relatively complex and disabling illness with a substantial economic burden and functional impairment. Until now, many CFS patients lack appropriate healthcare. Acupoint catgut embedding is an effective and emerging alternative therapy for CFE. With this research, we endeavor to investigate the effect and safety of ACE for CFS.

Methods: Eight databases will be searched from inception to December 2020: PubMed, EMBASE, The Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chong-Qing VIP database, and Wan-fang database. We regard studies as eligible for inclusion if they were RCTs done in CFS patients, compare acupoint catgut embedding to another treatment strategy, and report fatigue changes at the end of the intervention period. Two independent reviewers complete the study selection, data extraction, and the risk of bias assessment. We assess pooled data using a random-effects model through Revman software (v.5.3) and Stata (version 15.0).

Ethics and dissemination: Ethics approval is not required because the individual patient data will not be involved, with no privacy concerns. This systematic review and meta-analysis will provide a reference for CFS patients and clinicians on the non-drug interventions. We will publish and disseminate the results of this review in a peer-reviewed journal or relevant conference.

Osf registration number: 10.17605/OSF.IO/7SHD9 (https://osf.io/7shd9).

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

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Figure 1
Flow chart of the study.
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References

    1. Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. 2015;Washington (DC): National Academies Press (US), PMID: 25695122. DOI: 10.17226/19012. - PubMed
    1. National Collaborating Centre for Primary Care (UK). Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (or Encephalopathy): Diagnosis and Management of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (or Encephalopathy) in Adults and Children [Internet]. 2007;London: Royal College of General Practitioners (UK), PMID: 21563329. - PubMed
    1. Myalgic encephalomyelitis: international consensus, criteria. J Intern Med 2017;282:353.doi: 10.1111/joim.12658. Erratum for: J Intern Med. 2011 Oct;270(4):327-38. PMID: 28929634; PMCID: PMC6885980. - PMC - PubMed
    1. Morris G, Puri BK, Walker AJ, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities. Pharmacol Res 2019;148:104450. - PubMed
    1. Jason LA, Brown A, Evans M, et al. Contrasting chronic fatigue syndrome versus myalgic encephalomyelitis/chronic fatigue syndrome. Fatigue 2013;1:168–83. - PMC - PubMed