Clinical Trial
doi: 10.1164/arrd.1977.116.5.871.
Subsensitivity to the bronchodilator action of albuterol produced by chronic administration
- PMID: 335936
- DOI: 10.1164/arrd.1977.116.5.871
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Clinical Trial
Subsensitivity to the bronchodilator action of albuterol produced by chronic administration
Am Rev Respir Dis.
1977 Nov.
Abstract
Evidence of bronchodilator subsensitivity was sought in studies using the specific beta2 adrenergic agonist, albuterol. After a period of 1 or 2 weeks off all oral sympathomimetic agents, the mean response of the patients to the first dose of albuterol was consistently greater than the response after a period during which the drug had been administered regularly. Maximal decrease in response occurred after 2 weeks' of treatment, and there was no further decrease after prolonged treatment with the same dose of albuterol for periods as long as 1 year.
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