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Review
. 2021 Jun;238(6):1401-1415.
doi: 10.1007/s00213-021-05784-0. Epub 2021 Feb 16.

Mechanism and therapeutic strategies of depression after myocardial infarction

Ying Yang  1 , Xuping Li  1 , Sixuan Chen  1 , Mingzhu Xiao  1 , Zhongqiu Liu  1 , Jingyan Li  2 , Yuanyuan Cheng  3
Affiliations
Review

Mechanism and therapeutic strategies of depression after myocardial infarction

Ying Yang et al. Psychopharmacology (Berl). 2021 Jun.

Abstract

Depression resulted as an important factor associated with the myocardial infarction (MI) prognosis. Patients with MI also have a higher risk for developing depression. Although the issue of depression after MI has become a matter of clinical concern, the molecular mechanism underlying depression after MI remains unclear, whereby several strategies suggested have not got ideal effects, such as selective serotonin reuptake inhibitors. In this review, we summarized and discussed the occurrence mechanism of depression after MI, such as 5-hydroxytryptamine (5-HT) dysfunction, altered hypothalamus-pituitary-adrenal (HPA) axis function, gut microbiota imbalance, exosomal signal transduction, and inflammation. In addition, we offered a succinct overview of treatment, as well as some promising molecules especially from natural products for the treatment of depression after MI.

Keywords: Depression; Inflammation; Myocardial infarction; Therapy.

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