Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun;238(6):1401-1415.
doi: 10.1007/s00213-021-05784-0. Epub 2021 Feb 16.

Mechanism and therapeutic strategies of depression after myocardial infarction

Ying Yang  1 , Xuping Li  1 , Sixuan Chen  1 , Mingzhu Xiao  1 , Zhongqiu Liu  1 , Jingyan Li  2 , Yuanyuan Cheng  3
Affiliations
Review

Mechanism and therapeutic strategies of depression after myocardial infarction

Ying Yang et al. Psychopharmacology (Berl). 2021 Jun.

Abstract

Depression resulted as an important factor associated with the myocardial infarction (MI) prognosis. Patients with MI also have a higher risk for developing depression. Although the issue of depression after MI has become a matter of clinical concern, the molecular mechanism underlying depression after MI remains unclear, whereby several strategies suggested have not got ideal effects, such as selective serotonin reuptake inhibitors. In this review, we summarized and discussed the occurrence mechanism of depression after MI, such as 5-hydroxytryptamine (5-HT) dysfunction, altered hypothalamus-pituitary-adrenal (HPA) axis function, gut microbiota imbalance, exosomal signal transduction, and inflammation. In addition, we offered a succinct overview of treatment, as well as some promising molecules especially from natural products for the treatment of depression after MI.

Keywords: Depression; Inflammation; Myocardial infarction; Therapy.

PubMed Disclaimer

References

    1. Amamoto T, Sarai K (1976) On the tryptophan-serotonin metabolism in manic-depressive disorders. Changes in plasma 5-HT and 5-HIAA levels and urinary 5-HIAA excretion following oral loading of L-5HTP in patients with depression. Hiroshima J Med Sci 25:135–140 - PubMed
    1. Anton Menarguez V, Sempere Ripoll JM, Martinez Amoros R (2019) Effectiveness of psychological intervention in cardiac rehabilitation. Semergen 45:288–294 - PubMed
    1. Arseneault-Bréard J, Rondeau I, Gilbert K, Girard SA, Tompkins TA, Godbout R, Rousseau G (2012) Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model. Br J Nutr 107:1793–1799
    1. Bah TM, Kaloustian S, Rousseau G, Godbout R (2011) Pretreatment with pentoxifylline has antidepressant-like effects in a rat model of acute myocardial infarction. Behav Pharmacol 22:779–784 - PubMed
    1. Berge T, Bull-Hansen B, Solberg EE, Heyerdahl ER, Jorgensen KN, Vinge LE, Aaronaes M, Oie E, Hyldmo I (2019) Screening for symptoms of depression and anxiety in a cardiology department. Tidsskr Nor Laegeforen 139

MeSH terms

LinkOut - more resources