Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988;21(3):265-7.
doi: 10.1007/BF00262783.

Renal impairment following the combined use of high-dose methotrexate and procarbazine

P Price  1 , H Thompson, E M Bessell, H J Bloom
Affiliations

Renal impairment following the combined use of high-dose methotrexate and procarbazine

P Price et al. Cancer Chemother Pharmacol. 1988.

Abstract

A major side-effect of high-dose methotrexate is renal toxicity, which may develop unexpectedly despite adequate standard precautions such as hydration and alkalinisation of the urine. The pathogenesis is unclear. Recent reports suggest that the combination of high-dose methotrexate with non-chemotherapeutic agents may cause such renal impairment. Three cases of unexpected renal impairment following the combined use of high-dose methotrexate and another cytotoxic agent, procarbazine, are reported. Possible mechanisms of this interaction are discussed, as are recommendations for future combined administration.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Cancer Treat Rep. 1980 Aug-Sep;64(8-9):989-91 - PubMed
    1. Cancer Treat Rep. 1977 Jul;61(4):745-8 - PubMed
    1. J Clin Oncol. 1983 Mar;1(3):208-16 - PubMed
    1. Cancer Treat Rep. 1978 Oct;62(10):1595-7 - PubMed
    1. Cancer. 1982 Dec 15;50(12):2775-9 - PubMed

MeSH terms

LinkOut - more resources