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Review
. 2021 Jun 16;106(7):1854-1866.
doi: 10.1210/clinem/dgab091.

Long-Term Weight Loss Strategies for Obesity

Karim Kheniser  1 , David R Saxon  2 , Sangeeta R Kashyap  3
Affiliations
Review

Long-Term Weight Loss Strategies for Obesity

Karim Kheniser et al. J Clin Endocrinol Metab. .

Abstract

Context: Obesity is a chronic disease that is difficult to manage without holistic therapy. The therapeutic armamentarium for obesity primarily consists of 4 forms of therapy: lifestyle modification (ie, diet and exercise), cognitive behavioral therapy, pharmacotherapy, and bariatric surgery.

Evidence acquisition: Evidence was consolidated from randomized controlled trials, observational studies, and meta-analyses.

Evidence synthesis: After 2 years, lifestyle interventions can facilitate weight loss that equates to ~5%. Even though lifestyle interventions are plagued by weight regain, they can have substantial effects on type 2 diabetes and cardiovascular disease risk. Although 10-year percentage excess weight loss can surpass 50% after bariatric surgery, weight regain is likely. To mitigate weight regain, instituting a multifactorial maintenance program is imperative. Such a program can integrate diet, exercise, and pharmacotherapy. Moreover, behavioral therapy can complement a maintenance program well.

Conclusions: Obesity is best managed by a multidisciplinary clinical team that integrates diet, exercise, and pharmacotherapy. Bariatric surgery is needed to manage type 2 diabetes and obesity in select patients.

Keywords: bariatric surgery; diet; exercise; obesity; pharmacotherapy.

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