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Review
. 2021 Mar;123(3):751-759.
doi: 10.1002/jso.26312.

Immunotherapy for pancreatic ductal adenocarcinoma

Eileen Carpenter  1 , Sarah Nelson  2 , Filip Bednar  2 , Clifford Cho  2 , Hari Nathan  2 , Vaibhav Sahai  3 , Marina Pasca di Magliano  2 , Timothy L Frankel  2
Affiliations
Review

Immunotherapy for pancreatic ductal adenocarcinoma

Eileen Carpenter et al. J Surg Oncol. 2021 Mar.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer with an urgent need for better medical therapies. Efforts have been made to investigate the efficacy of immunotherapy, particularly given the hallmarks of immune suppression and exhaustion in PDAC tumors. Here, we review the molecular components responsible for the immune-privileged state in PDAC and provide an overview of the immunotherapeutic strategies for PDAC including vaccine therapy, checkpoint blockade, myeloid-targeted therapy, and immune agonist therapy.

Keywords: immunotherapy; microenvironment; pancreatic cancer.

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References

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