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. 2021 Aug;26(4):323-325.
doi: 10.1080/13625187.2021.1887475. Epub 2021 Feb 17.

An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users

Aaron Lazorwitz  1 , Jeanelle Sheeder  1 , Stephanie Teal  1
Affiliations

An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users

Aaron Lazorwitz et al. Eur J Contracept Reprod Health Care. 2021 Aug.

Abstract

Purpose: To explore how diet and exercise habits associate with serum etonogestrel concentrations among contraceptive implant users.

Materials and methods: We conducted a secondary analysis of healthy, reproductive-age women using etonogestrel implants. This study was registered on ClinicalTrials.gov, NCT03092037. We assessed diet and exercise habits with two validated surveys: Healthy Eating Vital Signs and the Stanford Brief Activity Survey. Participants previously had their serum etonogestrel concentrations measured using a validated liquid-chromatography mass-spectrometry assay. We then used linear modelling to test for associations between survey responses and serum etonogestrel concentrations.

Results: Among 129 participants, diet and exercise habits had no significant associations with serum etonogestrel concentrations (p = 0.22-0.72), with inconsistent effects found for increased caloric intake and sedentary lifestyle.

Conclusion: This exploratory study found no significant effect of diet or exercise habits on steady-state pharmacokinetics among contraceptive implant users.

Clinical trial registration: Clinicaltrials.gov: NCT03092037.

Keywords: Lifestyle; contraceptive implant; diet; etonogestrel; exercise; pharmacokinetics.

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References

    1. Lazorwitz A, Aquilante CL, Sheeder J, et al. Relationship between patient characteristics and serum etonogestrel concentrations in contraceptive implant users. Contraception. 2019. July;100(1):37–41. - PMC - PubMed
    1. Le J, Tsourounis C. Implanon: a critical review. The Annals of pharmacotherapy. 2001. March;35(3):329–36. - PubMed
    1. McNicholas C, Swor E, Wan L, et al. Prolonged use of the etonogestrel implant and levonorgestrel intrauterine device: 2 years beyond Food and Drug Administration-approved duration. American journal of obstetrics and gynecology. 2017. June;216(6):586.e1–586.e6. - PMC - PubMed
    1. Lazorwitz A, Aquilante CL, Oreschak K, et al. Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users. Obstetrics and gynecology. 2019. Apr;133(4):783–794. - PMC - PubMed
    1. Yang CS. Influences of Dietary and Other Factors on Xenobiotic Metabolism and Carcinogenesis-A Review Article in Memory of Dr. Allan H. Conney (1930–2013). Nutrition and cancer. 2015;67(8):1207–13. - PubMed

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