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. 2021 Aug;26(4):323-325.
doi: 10.1080/13625187.2021.1887475. Epub 2021 Feb 17.

An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users

Aaron Lazorwitz  1 , Jeanelle Sheeder  1 , Stephanie Teal  1
Affiliations

An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users

Aaron Lazorwitz et al. Eur J Contracept Reprod Health Care. 2021 Aug.

Abstract

Purpose: To explore how diet and exercise habits associate with serum etonogestrel concentrations among contraceptive implant users.

Materials and methods: We conducted a secondary analysis of healthy, reproductive-age women using etonogestrel implants. This study was registered on ClinicalTrials.gov, NCT03092037. We assessed diet and exercise habits with two validated surveys: Healthy Eating Vital Signs and the Stanford Brief Activity Survey. Participants previously had their serum etonogestrel concentrations measured using a validated liquid-chromatography mass-spectrometry assay. We then used linear modelling to test for associations between survey responses and serum etonogestrel concentrations.

Results: Among 129 participants, diet and exercise habits had no significant associations with serum etonogestrel concentrations (p = 0.22-0.72), with inconsistent effects found for increased caloric intake and sedentary lifestyle.

Conclusion: This exploratory study found no significant effect of diet or exercise habits on steady-state pharmacokinetics among contraceptive implant users.

Clinical trial registration: Clinicaltrials.gov: NCT03092037.

Keywords: Lifestyle; contraceptive implant; diet; etonogestrel; exercise; pharmacokinetics.

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References

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