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. 1977 Oct;12(4):555-6.
doi: 10.1128/AAC.12.4.555.

Cyclic thymineless death significantly increases frequency of R-plasmid elimination

M J Tribe, R J Pinney

Cyclic thymineless death significantly increases frequency of R-plasmid elimination

M J Tribe et al. Antimicrob Agents Chemother. 1977 Oct.

Abstract

Thymine starvation of Escherichia coli strain C600 thy (R46) eliminated the R plasmid at a frequency of 17%. This was increased fourfold, to 68%, after the same culture was subjected to an additional three cycles of growth followed by thymineless death.

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