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. 2021 Apr;41(4):1558-1569.
doi: 10.1161/ATVBAHA.120.315530. Epub 2021 Feb 18.

Ceramide Scores Predict Cardiovascular Risk in the Community

Vlad C Vasile  1   2 , Jeffrey W Meeusen  1 , Jose R Medina Inojosa  2 , Leslie J Donato  1 , Christopher G Scott  3 , Meredith S Hyun  3 , Manlio Vinciguerra  4 , Richard R Rodeheffer  2 , Francisco Lopez-Jimenez  2 , Allan S Jaffe  1   2
Affiliations

Ceramide Scores Predict Cardiovascular Risk in the Community

Vlad C Vasile et al. Arterioscler Thromb Vasc Biol. 2021 Apr.

Abstract

[Figure: see text].

Keywords: atherosclerosis; cardiovascular disease; ceramide; coronary artery disease; risk factors.

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Figures

FIGURE 1.
FIGURE 1.. Cohort selection-
a flow chart of patients included in our study. MACE major adverse cardiac events.
FIGURE 2.
FIGURE 2.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (2a), (24:1)/(24:0) (2b) and ceramide score (2c) by ASCVD cutoff point quartiles.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 2.
FIGURE 2.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (2a), (24:1)/(24:0) (2b) and ceramide score (2c) by ASCVD cutoff point quartiles.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 2.
FIGURE 2.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (2a), (24:1)/(24:0) (2b) and ceramide score (2c) by ASCVD cutoff point quartiles.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 3.
FIGURE 3.. Dose response curve of ceramide ratios and score with MACE.
Forrest plot of ceramide ratios and score by quartiles in relationship with MACE expressed as HR. MACE major adverse cardiac events events; HR hazard ratio
FIGURE 4.
FIGURE 4.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (4a), (24:1)/(24:0) (4b) and ceramide score (4c) by ASCVD risk categories.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 4.
FIGURE 4.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (4a), (24:1)/(24:0) (4b) and ceramide score (4c) by ASCVD risk categories.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 4.
FIGURE 4.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (4a), (24:1)/(24:0) (4b) and ceramide score (4c) by ASCVD risk categories.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
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