Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr;41(4):1558-1569.
doi: 10.1161/ATVBAHA.120.315530. Epub 2021 Feb 18.

Ceramide Scores Predict Cardiovascular Risk in the Community

Vlad C Vasile  1   2 , Jeffrey W Meeusen  1 , Jose R Medina Inojosa  2 , Leslie J Donato  1 , Christopher G Scott  3 , Meredith S Hyun  3 , Manlio Vinciguerra  4 , Richard R Rodeheffer  2 , Francisco Lopez-Jimenez  2 , Allan S Jaffe  1   2
Affiliations

Ceramide Scores Predict Cardiovascular Risk in the Community

Vlad C Vasile et al. Arterioscler Thromb Vasc Biol. 2021 Apr.

Abstract

[Figure: see text].

Keywords: atherosclerosis; cardiovascular disease; ceramide; coronary artery disease; risk factors.

PubMed Disclaimer

Figures

FIGURE 1.
FIGURE 1.. Cohort selection-
a flow chart of patients included in our study. MACE major adverse cardiac events.
FIGURE 2.
FIGURE 2.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (2a), (24:1)/(24:0) (2b) and ceramide score (2c) by ASCVD cutoff point quartiles.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 2.
FIGURE 2.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (2a), (24:1)/(24:0) (2b) and ceramide score (2c) by ASCVD cutoff point quartiles.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 2.
FIGURE 2.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (2a), (24:1)/(24:0) (2b) and ceramide score (2c) by ASCVD cutoff point quartiles.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 3.
FIGURE 3.. Dose response curve of ceramide ratios and score with MACE.
Forrest plot of ceramide ratios and score by quartiles in relationship with MACE expressed as HR. MACE major adverse cardiac events events; HR hazard ratio
FIGURE 4.
FIGURE 4.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (4a), (24:1)/(24:0) (4b) and ceramide score (4c) by ASCVD risk categories.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 4.
FIGURE 4.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (4a), (24:1)/(24:0) (4b) and ceramide score (4c) by ASCVD risk categories.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
FIGURE 4.
FIGURE 4.. Survival by Kaplan Meier curves of for ceramides (18:0)/(24:0) (4a), (24:1)/(24:0) (4b) and ceramide score (4c) by ASCVD risk categories.
ASCVD atherosclerotic cardiovascular disease; Cer ceramides; MI myocardial infarction
None
See this image and copyright information in PMC

References

    1. Collaborators GBDCoD. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1736–1788. - PMC - PubMed
    1. Dawber TR, Kannel WB and McNamara PM. The Prediction of Coronary Heart Disease. Trans Assoc Life Insur Med Dir Am 1964;47:70–105. - PubMed
    1. Kannel WB, Dawber TR, Friedman GD, Glennon WE and McNamara PM. Risk Factors in Coronary Heart Disease. An Evaluation of Several Serum Lipids as Predictors of Coronary Heart Disease; the Framingham Study. Ann Intern Med 1964;61:888–99. - PubMed
    1. Prospective Studies C, Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J, Qizilbash N, Peto R and Collins R. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370:1829–39. - PubMed
    1. Emerging Risk Factors C, Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, Thompson A, Wood AM, Lewington S, Sattar N, Packard CJ, Collins R, Thompson SG and Danesh J. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302:1993–2000. - PMC - PubMed

Publication types

MeSH terms