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Case Reports
. 2021 Feb;49(2):300060520985657.
doi: 10.1177/0300060520985657.

Small cell carcinoma of the cervix complicated by syndrome of inappropriate antidiuretic hormone secretion: a case report

Cai-Fu Zhao  1 , Su-Fen Zhao  1 , Ze-Qing Du  1
Affiliations
Case Reports

Small cell carcinoma of the cervix complicated by syndrome of inappropriate antidiuretic hormone secretion: a case report

Cai-Fu Zhao et al. J Int Med Res. 2021 Feb.

Abstract

Small cell carcinoma of the cervix is a rare malignant tumor in the clinical setting. Clinical manifestations of this tumor are mostly similar to those of normal types of cervical cancer. Small cell carcinoma of the cervix only shows symptoms of neuroendocrine tumors, such as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Most of the hyponatremia caused by SIADH can be managed after removal of the cause. Hyponatremia is a predictor of poor prognosis and can be used as an indicator of partial recurrence. We report a case of small cell carcinoma of the cervix complicated by SIADH. Our patient presented with irregular vaginal bleeding after menopause. After one cycle of chemotherapy, there was trembling of the limbs, and a laboratory examination showed low Na+ and low Cl- levels. After limited water intake, intravenous hypertonic saline, and intermittent diuretic treatment, the patient's blood Na+ levels returned to normal. After a radical operation, the above-mentioned symptoms disappeared.

Keywords: Small cell carcinoma of the cervix; chemotherapy; electrolyte; hyponatremia; neuroendocrine tumor; syndrome of inappropriate antidiuretic hormone secretion.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Contrast-enhanced computed tomography of the pelvis (a). The arrow indicates a cervical lesion, which is approximately 4.8 × 5.7 × 6.2 cm3 in size. The lesion shows uneven enhancement, and an unclear boundary between the local cervix and posterior wall of the bladder. Dissected specimen postoperatively (b). Cervical swelling of approximately 5 cm in diameter can be seen. Additionally, there was a hard endogenous mass in the cervical canal, which was located in the posterior wall of the cervix, and an enlarged lymph node with a diameter of approximately 1 cm in the right inguinal region. Image showing pathology under a light microscope (c) (hematoxylin and eosin, × 100). Cervical cancer cells and tumor thrombus were found in the vasculature.
See this image and copyright information in PMC

References

    1. Atienza-Amores M, Guerini-Rocco E, Soslow RA, et al. Small cell carcinoma of the gynecologic tract: A multifaceted spectrum of lesions. Gynecol Oncol 2014; 134: 410–418. - PubMed
    1. Crowder S, Tuller E. Small cell carcinoma of the female genital tract. Semin Oncol 2007; 34: 57–63. - PubMed
    1. Kurman R, Carcangiu M, Herrington C, et al. WHO classification of tumours of female reproductive organs. Lyon: IARC Press, 2014, pp.196–198.
    1. Zheng X, Liu D, Fallon JT, et al. Distinct genetic alterations in small cell carcinoma from different anatomic sites. Exp Hematol Oncol 2015; 4: 2–9. - PMC - PubMed
    1. Wang Z, Wu L, Yao H, et al . Clinical analysis of 32 cases with neuroendocrine carcinoma of the uterine cervix in early-stage disease. Zhonghua Fu Chan Ke Za Zhi 2015; 50: 198–203. - PubMed

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